Ovulation control by regulating nitric oxide levels with arginin

Details Ovulation control by regulating nitric oxide levels with arginin Ovulation control by regulating nitric oxide levels with arginin

1993-12-10

1995-11-28

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514561, 514563, 514565, 514841, 514843, A61K 31195, A61K 3156

Patent

active

054708478

ABSTRACT:
Inhibition of ovulation in a female may be achieved by administering an arginine derivative which acts as a nitric oxide sythase inhibitor, alone or in combination with one or more of a progestin, an estrogen, and an LH-RH antagonist, thereby preventing conception.

REFERENCES:
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patent: 5028627 (1991-07-01), Kilbourn et al.
Colton, F. B., "Steroids and `the Pill`: early steroid research at Searle," Steroids, 57:624-630 (Dec. 1992).
Ellman, et al., "IL-1.beta.-Induces the Formation of Nitric Oxide by Heterologous Ovarian Cells: Possible Role of Nitric Oxide in Ovulation," FASEB J. 7(7):A1115, abstract 366 (1993).
Fathalla, M. F., "Contraception and women's health," Brit. Med. Bull., 49(1):245-251 (1993).
Hannaford, P. C., "Cervical cancer and methods of contraception," Advances in Contraception, 7:317-324 (1991).
Jordan et al., "The Estrogenic Activity of Synthetic Progestins Used in Oral Contraceptives," Cancer Supp., 71(4):1501-1505 (Feb. 15, 1993).
Segal, S. J., "Trends in Population and Contraception," Annals. Med., 25:51-56 (1993).
Szarewski, et al., "Contraception, Current state of the art," Brit. J. Med., Brit. Med. J., 1224-1226 (1991).

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