Ovulation control by regulating nitric oxide levels

Details Ovulation control by regulating nitric oxide levels Ovulation control by regulating nitric oxide levels

1995-06-07

1997-07-01

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514565, 514742, 514843, A61K 3134, A61K 31195, A61K 31045

Patent

active

056439440

ABSTRACT:
The stimulation of ovulation in a female may be achieved by administering a nitric oxide source, optionally in further combination with one or more of clomiphene, a gonadotropin, and an LH-RH agonist.

REFERENCES:
patent: 4339434 (1982-07-01), Ericsson
patent: 4851385 (1989-07-01), Rueske
patent: 5068221 (1991-11-01), Mathias
patent: 5130137 (1992-07-01), Crowley, Jr.
Bonello et al., "Inhibition of Nitric Oxide: Effects on Interleukin-1.beta.-Enhanced Ovulation Rate, Steriod Hormones, and Ovarian Leukocyte Distribution at Ovulation in the Rat, " Biology of Reproduction, 54:436-445, 1996.
Mani et al., "Nitric Oxide Mediates Sexual Behavior in Female Rats," Proc. Natl. Acad. Sci., 91:6468-6472, Jul. 1994.
Shukovski and Tsafriri, "The Involvement of Nitric Oxide in the Ovulatory Process in the Rat," Endocrinology, 135(5):2287-2290, 1994.
Van Voorhis et al., "Nitric Oxide: An Autocrine Regulator of Human Granulosa-Luteal Cell Steroidogenesis," 135(5):1799-1806, 1994.

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