Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1995-03-02
1997-09-23
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530326, 530367, 530368, 530412, 530416, 530427, 530827, C07K 100, A23J 100
Patent
active
056706294
ABSTRACT:
An ovoglycoprotein has a molecular weight of 30,000 daltons which is determined by a matrix-assisted laser desorption ionization time-of-flight type mass spectrometer, an amino acid sequence of 15 residues from the N-terminal represented by Thr-Glu-Ser-Pro-Xaa-Ser-Ala-Pro-Leu-Val-Pro-Ala-Asp-Met-Asp (wherein Xaa represents a cysteine residue or an amino acid residue having a sugar chain linked thereto) (SEQ ID NO:1) and a sugar content of about 25% by weight and free of trypsin-inhibitory activity and a resolution agent for chromatography comprises a fixed phase which comprises a carrier and the foregoing ovoglycoprotein linked to the carrier. The agent for resolving optical isomers is not expensive, and is stable and highly resistant to deterioration by organic solvents, excellent in liquid-flow through properties, has a high sample-loading rate and permits efficient resolution of optical isomers of a chiral compound.
REFERENCES:
Ketterer, Biochem. J., vol. 96, No. 2, pp. 372-376, 1965.
Database Abstract WPI, Derwent Publication, AN. 91-373560/51 (JP 3 251544, Nov. 11, 1991).
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Haginaka et al, Anal. Chem., vol. 67, No. 15, pp. 2539-2547, Aug., 1995.
Archives of Biochemistry and Biophysics, vol. 160, No. 1, pp. 26-39, 1974, Theodore R. Oegama, Jr., et al., "The Physical and Chemical Properties of a Chicken Egg White Glycoprotein Purified by Nondenaturing Methodology".
Biochem. J., vol. 96, No. 2, pp. 372-376, 1965, B. Ketterer, "Ovoglycoprotein, A Protein of Hen's-Egg White".
Fujima Hiroya
Haginaka Jun
Wada Hiroo
Mohamed Abdel A.
Shinwa Chemical Industries, Ltd.
Tsang Cecilia J.
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