Ovine GRF

Details Ovine GRF Ovine GRF

1984-03-02

1986-08-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3743, C07K 710

Patent

active

046056432

ABSTRACT:
A synthetic peptide is extremely potent in stimulating the release of pituitary GH in mammals, particularly in sheep, since it is the replicate of the native (hormone) releasing factor of the sheep hypothalamus. It contains the following sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Ile-Leu-Gly-Gln-Leu-Ser-Al a-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Asn-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu-G ln-Gly-Ala-Lys-Val-Arg-Leu. This peptide or a biologically active fragment thereof, or analogs thereof having well-known substitutions and/or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals and may be used diagnostically. The peptide is particularly useful in stimulating the release of GH so as to accelerate growth in warm-blooded non-human animals, particularly sheep, and/or to improve aquiculture.

REFERENCES:
patent: 4118483 (1978-10-01), Konig et al.
patent: 4395400 (1983-07-01), Konig et al.
Wilson et al., Neuroendocrinology, 15, 313-327 (1974).
Yue et al., Diabetes, 24 (No. 7), 625-632 (1975).
Esch et al., Biochemical and Biophysical Research Communications, vol. 117, No. 3, 772-779 (1983).
Chemical Abstracts, vol. 81, 1974, Abst. No. 117701t.

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