Oviductal catalase binding to the membranes of spermatozoa and u

Details Oviductal catalase binding to the membranes of spermatozoa and u Oviductal catalase binding to the membranes of spermatozoa and u

1997-02-19

1999-07-06

Isabella, David J.

Surgery

Reproduction and fertilization techniques

Artificial insemination

435 2, A61B 1743, C12N 500

Patent

active

059191279

ABSTRACT:
The present invention relates to a novel oviductal catalase having a molecular weight of about 60 KDa and which binds to a spermatozoa membrane outer surface, wherein said catalase once bound to the spermatozoa membrane outer surface protects said spermatozoa against oxidation. A method of stabilizing spermatozoa membrane and improving spermatozoa survival during migration in oviduct and/or uterus for artificial insemination; which comprises coating spermatozoa with such a catalase enzyme. A method of improving spermatozoa survival during migration in oviduct and/or uterus in cases of female infertility due to the absence of endogenous catalase in the genital tract of the female subject; which comprises administering catalase in the female genital tract before coit or coating spermatozoa with a catalase enzyme for artificial insemination. Also provided herein are method of diagnostic of male or female infertility.

REFERENCES:
Parrish JJ et al., 1988, Biol. Reprod., 38:1171-1180.
Alvarez JG et al., 1987, J. Androl., 8:338-348.
Aitken RJ, 1994, Reprod. Fertil. Dev., 6:19-24.
Aitken RJ, 1995, Reprod. Fertil. Dev., 7:659-668.

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