Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Reexamination Certificate
2010-03-31
2011-11-22
Lucchesi, Nicholas D (Department: 3763)
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
C604S066000, C600S365000
Reexamination Certificate
active
08062249
ABSTRACT:
A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”). The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during simulated overnight closed-loop control with the MPC algorithm using the glucose measurement error model suggesting that the continuous glucose monitoring technologies facilitate safe closed-loop insulin delivery.
REFERENCES:
patent: 7920906 (2011-04-01), Goode et al.
patent: 2007/0173761 (2007-07-01), Kanderian et al.
patent: 2008/0071158 (2008-03-01), McGarraugh et al.
patent: 2008/0161664 (2008-07-01), Mastrototaro et al.
patent: 2008/0183060 (2008-07-01), Steil et al.
patent: 2007/116226 (2007-10-01), None
Budiman Erwin S.
Hayter Gary A.
Hovorka Roman
Taub Marc B.
Wilinska Malgorzata E.
Abbott Diabetes Care Inc.
Cambridge Enterprise Limited
Fulwider Patton LLP
Lucchesi Nicholas D
Vu Quynh-Nhu H
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