Ovarian cancer ascites factor, in isolated form

Details Ovarian cancer ascites factor, in isolated form Ovarian cancer ascites factor, in isolated form

1993-04-02

1994-01-11

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Body fluid or exudate or transudate other than snake venom,...

424559, 424573, A61K 4500, A61K 3512

Patent

active

052779173

ABSTRACT:
Herein described is an ovarian cancer activating factor that has been isolated from ovarian cancer ascites fluid. The factor may be utilized in its isolated form in a screening program aimed at identifying inhibitors of factor-mediated ovarian cancer activation, or as a growth supplement useful for culturing ovarian and other cancer cell lines.

REFERENCES:
Bligh et al., "A rapid method of total lipid extraction and purification" Can. J. Biochem. Physiol., 1959, 37:911.
Buick et al., "Comparative properties of five human ovarian adenocarcinoma cell lines" Cancer Research, 1985, 45:3668.
Mills et al., "A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action" Cancer Research, 1988, 48:1066.
Mills et al., "Role of growth factors: their receptors and signalling pathways in the diagnosis, prognosis, follow-up and therapy of ovarian cancer" Diagn. Oncol., 1992, 2:39.
Mills et al., "Regulation of growth of human ovarian cancer cells". Ovarian Cancer 2: Biology Diagnosis and Management (Eds. Sharp, et al.), Chapman and Hall, London, 1992, pp. 127-143.
Mills et al., "Regulatory mechanisms in ascitic fluid" Ovarian Cancer: Biologic and therapeutic challenges. (Eds. F. Sharp et al.) Chapman and Hall Medical, London, 1989, pp. 55-62.
Mills et al., "Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian cancer cells" J. Clin. Invest., 1990, 86:851.
Schact "Extraction and purification of polyphosphoinositides" Methods Enzymol., 1981, 72:626.

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