Ovarian cancer ascites factor, in isolated form

Details Ovarian cancer ascites factor, in isolated form Ovarian cancer ascites factor, in isolated form

1993-10-01

1994-07-05

Russel, Jeffrey E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 723, 436501, 436 64, 436 71, 514 75, 554 78, C12Q 102, C12Q 100, G01N 33566, A61K 3166

Patent

active

053266900

ABSTRACT:
Herein described is an ovarian cancer activating factor that has been isolated from ovarian cancer ascites fluid. The factor may be utilized in its isolated form in a screening program aimed at identifying inhibitors of factor-mediated ovarian cancer activation, or as a growth supplement useful for culturing ovarian and other cancer cell lines.

REFERENCES:
Bligh et al, "A Rapid Method of Total Lipid Extraction and Purification", Can. J. Biochem. Physiol., 1959, 37:911.
Buick et al, "Comparative Properties of Five Human Ovarian Adenocarcinoma Cell Lines", Cancer Research, 1985, 45:3668.
Mills et al, "A Putative New Growth Factor in Ascitic Fluid from Ovarian Cancer Patients: Identification, Characterization, and Mechanism of Action", Cancer Research, 1988, 48:1066.
Mills et al, "Role of Growth Factors: Their Receptors and Signalling Pathways in the Diagnosis, Prognosis, follow-up and Therapy of Ovarian Cancer", Diagn. Oncol., 1992, 2:39.
Mills et al, "Regulation of Growth of Human Ovarian Cancer Cells", Ovarian Cancer 2: Biology Diagnosis and Management (Eds. Sharp, et al) Chapman and Hall Medical, London, 1992, pp. 127-143.
Mills et al, "Regulatory Mechanisms in Ascitic Fluid", Ovarian Cancer: Biologic and Therapeutic Challenges, (Eds. F. Sharp et al) Chapman and Hall Medical, London, 1989, pp. 55-62.
Mills et al, "Ascitic Fluid from Human Ovarian Cancer Patients Contains Growth Factors Necessary for Intraperitoneal Growth of Human Ovarian Cancer Cells", J. Clin. Invest., 1990, 86: 851.
Schact, "Extraction and Purification of Polyphosphoinositides", Methods Enzymol., 1981, 72:626.

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