Outer membrane vesicles and uses thereof

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07628995

ABSTRACT:
The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.

REFERENCES:
patent: WO2004/014418 (2004-02-01), None
Bowie et al. (Science, 1990, 247:1306-1310).
Greenspan et al. (Nature Biotechnology, 7:936-937, 1999).
Cruse et al., Illustrated Dict. of Immunology, 2nd ed., CRC Press, 2003, p. 46, 166, 382.
McGuinness et al. (Mol. Microbiol., 7:505-514, 1993).
Moudallal et al. (EMBO Journal, 1:1005-1010, 1982).
Bos, Martine, et al. “Identification of an outer membrane protein required for the transport of lipopolysaccharide to the bacterial cell surface.” vol. 101, No. 25, pp. 9417-9422 (2004).
Braun, Martin, et al. “Imp/OstA is required for cell envelope biogenesis in Escherichia coli.” vol. 45, No. 5, pp. 1289-1302 (2002).
Genevrois, Stephanie, et al., “The Omp85 protein of Neisseria meningitidis is required for lipid export to the outer membrane.” vol. 22, No. 8, pp. 1780-1789 (2003).
Steeghs, L. et al., “Meningitis bacterium is viable without endotoxin.” vol. 392, No. 6675, pp. 449-450 (1998).
Morley, S.L. et al., “Vaccine prevention of meningococcal disease, coming soon?” vol. 20, No. 5-6, pp. 666-687 (2001).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Outer membrane vesicles and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Outer membrane vesicles and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Outer membrane vesicles and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4145187

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.