Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2005-05-17
2005-05-17
Swartz, Rodney P (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C424S185100, C424S190100, C424S191100, C424S234100, C435S243000, C530S300000, C530S350000, C536S023700, C536S023740, C536S023740
Reexamination Certificate
active
06893640
ABSTRACT:
Diagnostic tools for for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane proteins ofE. chaffeensisand variants thereof, referred to hereinafter as the “OMP proteins”, a group of outer membrane proteins ofE. canisand variants thereof referred to hereinafter as the “P30F proteins”, and antibodies to the OMP proteins and the P30F proteins. The OMP proteins ofE. chaffeensisencompass OMP-1, OMP-1A, OMP1-B, OMP-1C, OMP1-D, OMP1-E, OMP1-F, OMP1-H, OMP-1R, OMP-1S, OMP-1T, OMP-1U, OMP-1V, OMP-1W, OMP-1X, OMP-1Y and OMP-1Z. The P30F proteins ofE. canisencompass P30, P30a, P30-1, P30-2, P30-3, P30-4, P30-5, P30-6, P30-7, P30-8, P30-9, P30-10, P30-11, and P30-12. Isolated polynucleotides that encode theE. chaffeensisOMP proteins and isolated polynucleotides that encode theE. canisP30F protein are also provided. The present invention also relates to kits containing reagents for diagnosing human ehrlichiosis and canine ehrlichiosis, and to immunogenic compositions containing one or more OMP proteins or P30F proteins.
REFERENCES:
patent: 5401656 (1995-03-01), Dawson
patent: 5413931 (1995-05-01), Dawson et al.
patent: 5789176 (1995-05-01), Dawson et al.
patent: 5869335 (1999-02-01), Munderloh et al.
patent: 6025338 (2000-02-01), Barbet et al.
patent: 6544517 (2003-04-01), Rikihisa et al.
patent: 9816554 (1998-04-01), None
“Transcriptional Analysis of p30 Major Outer Membrane Multigene Family ofEhrlichia canisin Dogs, Ticks, and Cell Celture at Different Temperatures” by Unver et al.,Infection and Immunity, vol. 69, No. 10, Oct. 2001, pp. 6172-6178.
“Transcriptional Analysis of p30 Major Outer Membrane Protein Genes ofEhrlichia canisin Naturally Infected Ticks and Sequence Analysis of p30-10 ofE. canisfrom Diverse Geographic Regions” by Felek et al.,Journal of Clinical Microbiology. vol. 41, No. 2, Feb. 2003. pp. 886-888.
“Cloning and Characterization of Multigenes Encoding the Immunodominant 30-Kilodalton Major Outer Membrane Proteins ofEhrlichia Canisand Application of the Recombinant Protein for Serodiagnosis” by Ohashi, et al.,Journal of Clinical Microbiology, vol. 36, No. 9, Sep. 1998, pp. 2671-2680.
“Immunodominant Major Outer Membrane Protein ofEhrlichia chaffeensisAre Encoded by a Polymorphic Multigene Family” by Ohashi, et al.,Infection and Immunity, vol. 66, No. 1, Jan. 1998, pp. 132-139.
Abstract D-79, “Binding of Outer Membrane Proteins ofEhrlichia chaffeenisto DHB2 Cells” by Zhang et al., 97th General Meeting of the American Society for Microbiology, Miami Beach, Florida, May 4-8, 199.
Abstract D-80, “Immunoprotective 28-kDa outer membrane protein ofEhrlichia chaffeensisis a member Of multi-sized protein antigen family” by Ohashi, et al., 97th General Meeting of the American Society for Microbiology, Miami Beach. Florida, May 408, 1997.
Abstract D-28, “Cloning, Sequencing, and Overexpression ofEhrlichia CanisImmunoreactive Protein Gene Homologous to Members ofEhrlichia Chaffeensis omp-1Gene Family” by Ohashi, et al., 98th General Meeting of the American Society for Microbiology, May 17-2, 1998, Atlanta, Georgia.
Abstract D-29, “Dot Immunoblot Assay for Crime Ehrlichiosis: Using Recombinant Major Protein Antigen ofEhrlichia Canis” by Unver, et al., 98th General Meeting of the American Society for Microbiology, May 17-21, 1998, Atlanta, Georgia.
GenBank Accession AF078553, Oct. 27, 1998.
GenBank Accession AF078554, Oct. 27, 1998.
GenBank Accession AF078555, Oct. 27, 1998.
GenBank Accession AF021338, Feb. 19, 1998.
GenBank Accession U72291, Feb. 19, 1998.
GenBank Accession L01987, Mar. 17, 1994.
GenBank Accession X74250, Oct. 10, 1994.
GenBank Accession U07862, Jan. 5, 1995.
GenBank Accession U36193, Aug. 8, 1996.
GenBank Accession U50830, Jul. 15, 1996.
GenBank Accession U50831, Jul. 15, 1996.
GenBank Accession U50832, Jul. 15, 1996.
GenBank Accession U50833, Jul. 15, 1996.
GenBank Accession U50834, Jul. 15, 1996.
GenBank Accession U50835, Jul. 15, 1996.
GenBank Accession AF062761, Jul. 19, 1998.
GenBank Accession AF068234, Jun. 8, 1998.
GenBank Accession AF077732, Aug. 13, 1998.
GenBank Accession AF077733, Aug. 13, 1998.
GenBank Accession AF077734, Aug. 13, 1998.
GenBank Accession AF077735, Aug. 13, 1998.
GenBank Accession AF082745, Oct. 20, 1998.
GenBank Accession AF082746, Oct. 20, 1998.
GenBank Accession AF082747, Oct. 20, 1998.
GenBank Accession AF082748, Oct. 20, 1998.
GenBank Accession AF082749, Oct. 20, 1998.
GenBank Accession AF082750, Oct. 20, 1998.
“Molecular Characterization of a 28 kDa Surface Antigen Family of the TribeEhrlichiae” by G. Reddy, et al.Biochemical and Biophysical Research Communications, vol. 247, No. 3, 1998, pp. 636-643.
“Sequence Heterogeneity of the Major Antigen Protein 1 Genes fromCowdria ruminantiumIsolates from Different Geographical Areas” by G. Reddy, et al.,Clinical and Diagnostic Laboratory Immunology, vol. 3, No. 4, Jul. 1996, pp. 417-422.
“Derivation of the completemsp4gene sequence ofAnaplasma marginalewithout cloning” by Oberle, et al.,Gene,vol. 136, Dec. 1993, pp. 291-294.
“Molecular Cloning, Sequence Analysis and Expression of the Gene Encoding the Immunodominant 32-Kilodalton Protein ofCowdria ruminantium” by van Vliet, et al.,Infection and Immunity, vol. 62, No. 4, Apr. 1994, pp. 1451-1456.
“Sequence and characterization of anEhrlichia chaffeensisgene encoding 314 amino acids highly homologous to the NAD A enzyme” by Yu, et al.,FEMS Microbiol Lett, Sep. 1, 1997, 154 (1), pp. 53-58.
“E: Enzyme-Linked Immunosorbent Assay and Western Immunoblot Analyses ofEhrlichia Canisand a Canine GranulocyticEhrlichiaInfection” by Rikihisa, et al.,Journal of Clinical Microbiology, vol. 20, No. 2, Jan. 1992, pp. 143-148.
“Serological evidence for antigenic relationships betweenEhrlichia canisandCowdria ruminatium” by Kelly, et al.,Res Vet Sci, 56 (2), Mar. 1994, pp. 170-174.
“The interface between research and the diagnoses of an emerging tick-borne disease, human ehrlichiosis due toEhrichia chaffensis” by Dawson, et al.,Archives of Journal of Medicine, vol. 156, No. 2, Jan. 22, 1996, pp. 137 (6).
“Western Immunoblotting analysis of the antibody responses of patients with human monocytotropicehrlichiosisto different strains ofEhrlichia chaffeensisandEhrlichia canis” by Chen, et al.,Clin Diagn Lab Immunol, Nov. 1997, 4 (6), pp. 731-735.
“Analysis and untrastructural localization ofEhrlichia chafeensisproteins with monoclonal antibodies” by Chen, et al,The American Journal of Tropical Medicine and Hygiene, 1996, 54 (4) pp. 405-412.
“Identification of the antigenic constituents ofEhrlichia chaffeensis” by Chen, et al.,Am J Trp Med HygJan. 1994, 50 (1) pp. 52-58.
“Antigenic characterization ofehrlichiae: a protein immunoblotting ofEhrlichia canis, Ehrlichia sennetsu,andEhrlichia risticii” by Brouqui, et al.,J Clin Microbiol, May 1992, 30 (5) pp. 1062-1066.
“Serologic diagnosis of human monocyticehrlichiosisby immunoblot analysis” by Brouqui, et al.,Clin Diagn Lab Immunol, Nov. 1994, 1(6) pp. 645-649.
Abstract D/B-126, “Characterization ofp30Multigene Family ofEhrlichia canis” by Ohashi, et al., Ninety-ninth General Meeting of the American Society for Microbiology, May 30-Jun. 3, 1999, Chicago, Illinois, p. 233.
Abstract D/B-138, “Western and Dot Blotting Analysis ofEhrlichia chaffeensi-IFA Positive and -Negative Human Sera Using Native and RecombinantE. chaffeensisandE. canisAntigen” by Unver, et al., Ninety-ninth General Meeting of the American Society for Microbiology, May 30-Jun. 3, 1999, Chicago, Illinois, p. 236.
“Molecular Cloning of the Gene for a Conserved Major Innumoreactive 28-Kilodalton Protein ofEhrlichia canis: a Potential Serodiagnostic Antigen” by McBride, et al.,Clini
Ohashi Norio
Rikihisa Yasuko
Calfee Halter & Griswold LLP
Swartz Rodney P
The Ohio State University Research Foundation
LandOfFree
Outer membrane protein of Ehrlichia canis and Ehrlichia... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Outer membrane protein of Ehrlichia canis and Ehrlichia..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Outer membrane protein of Ehrlichia canis and Ehrlichia... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3378446