Osteoprotegerin binding proteins

Details Osteoprotegerin binding proteins Osteoprotegerin binding proteins

1997-04-16

1998-12-01

Carlson, Karen

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

514 2, 530350, 530300, C12Q 100, C07K 1400

Patent

active

058436782

ABSTRACT:
A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host cells for production, methods of preparing osteoprotegerin binding protein, and binding assays are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget's disease are also provided.

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