Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1997-11-18
2000-01-18
Campell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 14, C12N 500
Patent
active
060159383
ABSTRACT:
The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 5169318 (1992-12-01), Levy
Adams et al. Science 252: 1651-1656 (1991).
Beutler et al. Ann. Rev. Biochem. 57, 505-518 (1988).
Brinster et al. PNAS USA 82, 4438-4442 (1985).
Capon et al. Nature 337, 525-531 (1989).
Chen et al. Chemistry 270, 2874-2878 (1995).
Chomczynski and Sacchi Anal. Biochem. 162, 156-159, (1987).
Fisher et al. Cell 81, 935-946 (1995).
Gennaro, Remington's Pharmaceutical Sciences, 18th ed., Mack Publishing (1990).
Goeddel et al. Cold Spring Harbor Symp. Quart. Biol. LI, 597-609 (1986).
Goeddel, Methods of Enzymology v. 185, Academic Press (1990).
Gribskov et al. PNAS USA 84, 4355-4358 (1987).
Harlow and Lane Antibodies: A Laboratory Manual Cold Spring Harbor Laboratory Press, Cold Spring Harbor N.Y. (1988).
Kohno et al. PNAS USA 87, 8331-8335 (1990).
Loetscher et al. Cancer Cells 3(6), 221-226 (1991).
Luethy et al. Protein Science 3, 139-146 (1994).
MacDonald et al. Meth. Enzymol. 152, 219 (1987).
Nagata et al. Science 267, 1449-1456 (1995).
Ogden et al. Meth. Enzymol 152, 61 (1987).
Pearson et al. Meth. Enzymol. 183, 63 (1990).
Simonet et al. J. Clin. Invest. 94, 1310-1319 (1994).
Smith et al. Cell 76, 959-962 (1994).
Suda et al. Cell 75, 1169-1178 (1993).
Boyle William J.
Calzone Frank J.
Chang Ming-Shi
Lacey David L.
Amgen Inc.
Campell Bruce R.
Levy Ron K.
Odre Steve M.
Winter Robert B.
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