Osteometrin related peptides and nucleic acids and diagnosis and

Details Osteometrin related peptides and nucleic acids and diagnosis and Osteometrin related peptides and nucleic acids and diagnosis and

1997-10-17

2000-03-14

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 100

Patent

active

060374497

ABSTRACT:
Bovine bone cells express osteometrin, a 35 kDA phosphoprotein specifically expressed in bone and dentin tissue. We have found that protein reactive with anti-osteometrin antisera is detectable in a wide range of species, and that osteometrin expression is detectable during mineralization of bone tissue. Our findings establish that osteometrin is an indicator of bone metabolism and may be involved in highly conserved aspects of bone and dentin metabolism. Osteometrin is used as a marker for osteoporosis and bone cancer.

REFERENCES:
patent: 5166058 (1992-11-01), Wang et al.
patent: 5552281 (1996-09-01), Stashenko et al.
Sakai et al. EMBO J. 13(16), 3748-56, 1994.
Celeste et al., "Identification of Transforming Growth Factor .beta. Family Members Present in Bone-inductive Protein Purified from Bovine Bone", Proc. Natl. Acad. Sci. 87:9843-9847, 1990.
Ohno et al., "A cDNA Cloning of Human AEBP1 from Primary Cultured Osteoblasts and Its Expression in a Differentiating Osteoblastic Cell Line", Biochemical and Biophysical Res. Comm. 228:411-414, 1996.
Delmas et al., "Identification of the Noncollagenous Proteins of Bovine Bone by Two-Dimensional Gel Electrophoresis", Calcif Tissue Int 36:308-316, 1984.
Laver et al., "Epitopes on Protein Antigens: Misconceptions and Realities", Cell 61:553-556, 1990.
Linde et al., "Mineral Induction by Immobilized Polyanionic Proteins", Calcif Tissue Int 44:286-295, 1989.
Uchiyama et al. "Isolation and Chemical Characterization of the Phosphoproteins of Chicken Bone Matrix: Heterogeneity in Molecular Weight and Composition", Biochemistry 25:7572-7583, 1986.
Zhou et al., "Stimulation by Bone Sialoprotein of Calcification in Osteoblast-Like MC3T3-E1 Cells", Calci Tissue Int 56:403-407, 1995.

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