Osteoinduction substance, method of manufacturing the same, and

Details Osteoinduction substance, method of manufacturing the same, and Osteoinduction substance, method of manufacturing the same, and

1996-07-22

1997-04-08

Brunsman, David

Compositions: coating or plastic

Coating or plastic compositions

Proteinaceous material containing

1061247, 424549, A61K 3532, A61K 970

Patent

active

056183399

ABSTRACT:
An osteoinduction substance is extracted from animal bones and essentially comprises Mg, Si, Ca, and Na. The osteoinduction substance is manufactured by subjecting the animal bone to acid dipping, liming, neutralization, thermal extraction, condensation, and dehydration to obtain gelatin. The gelatin is then subjected to deproteinization under a nonheat or a low-temperature condition to extract the osteoinduction substance. The osteoinduction substance is mixed with at least one of hydroxyapatite powder and chitosan to form a bone filling material. When the osteoinduction substance is mixed with chitosan sol, a bone filling material of a sheet type is obtained.

REFERENCES:
patent: 4394370 (1983-07-01), Jefferies
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4627982 (1986-12-01), Seyedin et al.
patent: 5001169 (1991-03-01), Nathan et al.
Holtz, CA 121:238351 "The osteoinductive . . . " 1994.

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