Surgery – Miscellaneous – Methods
Reexamination Certificate
2005-05-31
2005-05-31
Isabella, David J (Department: 3738)
Surgery
Miscellaneous
Methods
C623S016110, C623S066100, C424S426000, C435S325000
Reexamination Certificate
active
06899107
ABSTRACT:
A method by which immune responses to cortical bone grafts and other substrates (e.g., cement, IPN, etc.) can be minimized and at the same time graft osteoinductive potential can be improved, and improved graft substrate materials are disclosed. The method of the invention provides new types of bone grafts that incorporate into host bone more thoroughly and more rapidly, eliminating long-term complications, such as fracture, non-union, infection, and rejection. In the method of the invention, bone grafts or other substrates are modified to have an osteoinductive surface modification that the recipient's body will accept as its own tissue type and therefore will not reject or otherwise cause to fail. The osteoinductive surface modification comprises a biopolymer matrix coating that is seeded with periosteal cells that have been previously harvested either from the graft recipient or from an allogenic or xenogenic donor source.
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Bondre Shrikar
Cattaneo Maurice V.
Gresser Joseph D.
Lewandrowski Kai-Uwe
Trantolo Debra J.
Cambridge Scientific, Inc.
Isabella David J
Pabst Patent Group LLP
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