Osteogenic proteins

Details Osteogenic proteins Osteogenic proteins

1992-09-24

1994-06-28

Nutter, Nathan M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530395, 530840, 435 691, 4351723, 4352351, 4353201, 4352401, 4352523, 935 18, 935 27, 935 31, 935 34, 935 38, 935 55, 935 62, 935 70, 935 72, 935 81, C12P 2102, C12P 1934, C12N 1500, C12N 700

Patent

active

053248198

ABSTRACT:
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid compositions, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.

REFERENCES:
patent: 4294753 (1981-10-01), Urist
patent: 4394370 (1983-07-01), Jefferies
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4455256 (1984-06-01), Urist
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4563489 (1986-01-01), Urist
patent: 4774322 (1988-09-01), Seyedin et al.
patent: 4804744 (1989-02-01), Sen
patent: 4810691 (1989-03-01), Seyedin et al.
patent: 4843063 (1989-06-01), Seyedin et al.
patent: 4877864 (1989-08-01), Wang et al.
patent: 4968590 (1990-11-01), Kuberasampath et al.
patent: 5011691 (1991-04-01), Oppermann et al.
patent: 5013649 (1991-05-01), Wang et al.
patent: 5013649 (1992-05-01), Wang et al.
patent: 5106626 (1992-04-01), Parsons et al.
patent: 5106748 (1992-04-01), Wozney et al.
patent: 5108922 (1992-04-01), Wang et al.
patent: 5116738 (1992-05-01), Wang et al.
patent: 5141905 (1992-08-01), Rosen et al.
patent: 5154931 (1992-10-01), Kruger et al.
patent: 5166058 (1992-11-01), Wang et al.
patent: 5187076 (1993-02-01), Wozney et al.
Wozney, J. M., et al., Science, vol. 242, pp. 1528-1534, Dec. 1988.
Ozkaynak, E., et al., The EMBO Journal, vol. 9, No. 7, pp. 2085-2093, Jul. 1990.
Abstract-Rosen et al. "Developmental Expression of Cartilage and Bone Specific Genes in the Rat Embryo", p. A35 No. 136.
Abstract-Wang et al. "Purification and Characterization of Cartilage and Bone Inducing Factors", p. A37 No. 146.
Abstract-Wozney et al. "Identification Through Molecular Cloning of Factors Involved in In Vivo Cartilage Formation", p. A37 No. 147.
Rosen et al., Connective Tissue Research (1989) 20:313-319 "Purification & Molecular Cloning of a Novel Group of BMPS & Localization . . . Developing Bone".
Abstract-Harada et al. "Characterization of a Protease Activity Attrib. to Human Recombinant Bone Morphogenetic Protein-1", p. 141 No. CH308.
Canalis et al. (1980) Science 210:1021-1023.
Glowacki et al. (1981) Lancet 1:959-963.
Reddi (1981) Collage Rel. Res. 1:209-226.
Sampath et al. (1981) Proc. Natl. Acad. Sci. USA 78:7599-7603.
Farley et al. (1982) Biochem 21:3508-3513.
Urist et al. (1983) Proc. Soc. Exp. Bio. Med. 173:194-199.
Sampath et al. (1983) Proc. Natl. Acad. Sci. USA 80:6591-6595.
Urist et al. (1984) Clin. Orth. Rel. Res. 187:277-280.
Urist et al. (1984) Proc. Natl. Acad. Sci. USA 81:371-375.
Reddi (1985) Journal of Biomedical Materials Res. 19:233-239.
Seyedin et al. (1985) Proc. Natl. Acad. Sci. USA 82:2267-2271.
Klausner (1985) Biotechnology 3:567-568.
Centrella et al. (1985) Proc. Natl. Acad. Sci. USA 82:7335-7339.
Weeks et al. (1987) Cell 51:861-867.
Sampath et al. (1987) Proc. Natl. Acad. Sci. USA 84:7109-7113.
LeGendre and Matsudaira (1988) Biotechniques 6:154-159.
Sampath & Reddi (1985) Extracellular Matrix: Structure and Function (A. H. Reddi, Ed.), Allen R. Liss, Publ. N.Y. pp. 412-428.
Wang et al. (1988) Calcified Tissue Int. (Suppl) Ab No. 146, p. A37.
Wozney et al. (1988) Calcified Tissue Int. (Sup.) Ab No. 146, p. A37.
Wang et al. II (1988) Proc. Natl. Acad. Sci. USA 85:9484-9488.
Wozney et al. II (1988) Science 242:1528-1534.
Colowick et al., (1987) Methods in Enzymology 146:294-312.
Olson et al., (1985) Analyt. Biochem. 146:232-237.
Seyedin et al., (1983) J. Cell Biol. 97:1950-1953.
Simpson, (1984) Trends Biochem. Sci. 9:527-530.
Maugh, (1982) Science 217:819.
Padgett et al., (1987) Nature 325:81-84.
Wang et al., (1990) Proc. Natl. Acad. Sci. USA 87:2220-2224.
Lyons et al., (1989) Proc. Natl. Acad. Sci. USA 86:4554-4558.

Affiliated with

Also associated with

Rating

Osteogenic proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Osteogenic proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Osteogenic proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2378135