Osteogenic product and process

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

623 16, 623 17, 623 22, A61F 228, A61F 232, A61F 244, A61K 3818

Patent

active

055631240

ABSTRACT:
Disclosed is a product which includes calcium carbonate and bone growth factor useful for the promotion of bone formation when implanted in the body. The calcium carbonate is preferably in the form of aragonite which can be recovered from naturally occurring coral. A preferred bone growth factor of the present invention is a protein mixture purified from bone. Also disclosed is a process for the induction of bone formation which includes implanting the product in a body. The product and process of the present invention are particularly useful in hip replacement operations, knee replacement operations, spinal fusion operations, repair of periodontal defects, treatment of osteoporosis, repair of bone tumor defects and repair of bone fractures.

REFERENCES:
patent: 3318774 (1967-05-01), Dingwall et al.
patent: 3458397 (1969-07-01), Meyers et al.
patent: 4294753 (1981-10-01), Urist
patent: 4356572 (1982-11-01), Guillemin et al.
patent: 4361471 (1982-11-01), Kosarek
patent: 4394370 (1983-07-01), Jefferies
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4440750 (1984-04-01), Glowacki et al.
patent: 4455256 (1984-06-01), Urist
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4596574 (1986-06-01), Urist
patent: 4608199 (1986-08-01), Caplan et al.
patent: 4619989 (1986-10-01), Urist
patent: 4620327 (1986-11-01), Caplan et al.
patent: 4627853 (1986-12-01), Campbell et al.
patent: 4627982 (1986-12-01), Seyedin et al.
patent: 4637931 (1987-01-01), Schmitz
patent: 4681763 (1987-07-01), Nathanson et al.
patent: 4743259 (1988-05-01), Bolander et al.
patent: 4761471 (1988-08-01), Urist
patent: 4774228 (1988-09-01), Seyedin et al.
patent: 4774277 (1988-09-01), Piez
patent: 4774322 (1988-09-01), Seyedin et al.
patent: 4789663 (1988-12-01), Wailace et al.
patent: 4789732 (1988-12-01), Urist
patent: 4795467 (1989-01-01), Piez et al.
patent: 4795804 (1989-01-01), Urist
patent: 4804744 (1989-02-01), Sen
patent: 4810691 (1989-03-01), Seyedin et al.
patent: 4843063 (1989-06-01), Seyedin et al.
patent: 4863732 (1989-09-01), Nathan et al.
patent: 4877864 (1989-10-01), Wang et al.
patent: 4888366 (1989-12-01), Chu et al.
patent: 4968590 (1990-11-01), Kuberasampath et al.
patent: 4975526 (1990-12-01), Kuberasampath et al.
patent: 4975527 (1990-12-01), Koezuka et al.
patent: 4992226 (1991-02-01), Piez et al.
patent: 5001169 (1991-03-01), Nathan et al.
patent: 5106748 (1992-04-01), Wozney et al.
patent: 5158934 (1992-10-01), Ammann et al.
patent: 5270300 (1993-12-01), Hunziker
patent: 5290763 (1994-03-01), Poser et al.
Aspenberg, et al., "Dose-Dependent Stimulation of Bone Induction by Basic Fibroblast Growth Factor in Rats", pp. 481-484, 1991, Acta Orthop Scand, vol. 62(5).
Block, et al., "Glycol Methacrylate Embedding Technique Emphasizing Cost Containment, Ultrarapid Processing, and Adaptability to a Variety of Staining Techniques", pp. 290-298, 1982 Lab. Med., vol. 13, May.
Cuevas, et al., "Basic Fibroblast Growth Factor (FGF) Promotes Cartilage Repair in Vivo, " pp. 611-618, 1988, Biochem. and Biophys. Research Comm., vol. 156(2), Oct.
Frenkel, et al., "Fibroblast Growth Factor: Effects on Osteogenesis and Chondrogenesis in the Chick Embryo," pp. 265-268, 1992, Acta Anatomica, vol, 143. No. 3, Nov.
Guillemin, et al., "Comparison of Coral Resorption and Bone Apposition with Two Natural Corals of Different Porosities," pp. 765-779, 1989, J. Biomed. Mater. Res., vol. 23.
Guillemin, et al., "The Use of Coral as a Bone Graft Substitute," pp. 557-567, 1987, J. Biomed. Mater. Res., vol. 21.
Hott, et al., "Osteoinductive Effet of Coral Implanted into Rat Bone Marrow," pp. 345-352, 1991, Cer. in Substit. and Recon. Surg.
Ohgushi, et al., "Bone Formation Process in Porous Calcium Carbonate and Hydroxyapatite," pp. 885-895, 1992, J. Biomed. Mater. Res.vol.26.
Pouliquen, et al., "Coral as a Substitute for Bone Graft in Posterior Spine Fusion in Childhood," pp. 272-280, 1989, French J. Orthop. Surg., vol. 3(3).
Reddi, "Regulation of Bone Differentiation by Local and Systemic Factors, " pp. 27-47, 1985, Bone and Min. Res., vol. 3.
Roux, et al., "Madreporic Coral: A New Bone Graft Substitute for Cranial Surgery, " pp. 510-513, 1988, J. Neurosurg., vol. 69, Oct.
Sampath, et al., "Isolation of Osteogenin, an Extracellular Matrix-Associated, Bone-Inductive Protein, by Heparin Affinity Chromatography," pp. 7109-7113, 1987, Proc. Natl. Acad. Sci. USA, vol. 84, Oct.
Sautier, et al., "In Vitro Bone Formation on Coral Granules," pp. 1079-1085, 1990, In Vitro Cell. Dev. Biol., vol. 26, Nov.
Shabana, et al., "Ultrastructural Study of the Effects of Coral Skeleton on Cultured Human Gingival Fibroblasts in Three-Dimensional Collagen Lattices," pp. 162-167, 1991, J. Mater. Science: Mater. in Med., vol. 2.
Souyris, et al., "Coral, a New Biomedical Material; Experimental and First Clinical Investigations on Madreporaria," pp. 64-69, 1985, J. Max.-Fac. Surg., vol. 13.
Clin. Orthop., vol. 59, issued 1968, Urist et al, "Inductive Substrates for Bone Formation", pp. 59-96.
PNAS, vol.85, issued Dec. 1988, Wang et al, "Purification and characterization of other . . . ", pp. 9484-9488.
Molec. Endocrin., vol. 5, issued 1991, Hammonds, Jr. et al, "Bone-Inducing Activity of Mature BMP 2b . . .", pp. 149-155.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Osteogenic product and process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Osteogenic product and process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Osteogenic product and process will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-57084

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.