Osteogenic factors

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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Details

424422, 424484, 424548, 424549, 530350, 530353, 530840, 623 16, A61F 228, A61K 3532, A61K 3712, C07K 1520

Patent

active

051066262

ABSTRACT:
The present invention provides an osteogenically active protein preparation characterized by a molecular weight of from about 31,000 to 34,000 daltons as characterized comprising a subunit identical to or homologous to a subunit in P3 OF 31-34, by non-reducing sodium dodecyl sulfate polyacrylamide gel electrophoresis and by the characteristic of eluting from a reverse phase high performance liquid chromatography column equilibrated with buffers containing trifluoroacetic acid and acetonitrile by eluting within the concentrations of 35% to 45% acetonitrile. The invention further provides improved methods for isolating such preparations and genes encoding all or a portion of polypeptide subunits of dimers comprising the osteogenic protein preparation.

REFERENCES:
Wang et al., Proc. Natl. Acad. Sci. U.S.A., 85, pp. 9484-9488, Dec. 1988.

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