Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1989-10-04
1992-04-21
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424422, 424484, 424548, 424549, 530350, 530353, 530840, 623 16, A61F 228, A61K 3532, A61K 3712, C07K 1520
Patent
active
051066262
ABSTRACT:
The present invention provides an osteogenically active protein preparation characterized by a molecular weight of from about 31,000 to 34,000 daltons as characterized comprising a subunit identical to or homologous to a subunit in P3 OF 31-34, by non-reducing sodium dodecyl sulfate polyacrylamide gel electrophoresis and by the characteristic of eluting from a reverse phase high performance liquid chromatography column equilibrated with buffers containing trifluoroacetic acid and acetonitrile by eluting within the concentrations of 35% to 45% acetonitrile. The invention further provides improved methods for isolating such preparations and genes encoding all or a portion of polypeptide subunits of dimers comprising the osteogenic protein preparation.
REFERENCES:
Wang et al., Proc. Natl. Acad. Sci. U.S.A., 85, pp. 9484-9488, Dec. 1988.
Grinna Lynn
Hersh Carol
Parsons Thomas F.
Sen Arup
Theofan Georgia
Azpuru Carlos
International Genetic Engineering, Inc.
Page Thurman K.
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