Osteogenic factors

Details Osteogenic factors Osteogenic factors

1986-09-05

1989-02-14

Welsh, Maurice J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530840, 424 95, A61K 3532, C07K 1300

Patent

active

048047449

ABSTRACT:
A protein extracted from demineralized bone matrix exhibiting bone-inducing activity is disclosed as well as a method for the rapid isolation and purification of the protein to an essentially homogeneous state. Pharmaceutically acceptable compositions containing the bone-inducing protein and suitable pharmaceutical carriers are also described.

REFERENCES:
patent: 4294753 (1981-10-01), Urist
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4627982 (1986-12-01), Seyedin et al.
Urist et al., "A Soluble Bone Morphogenetic Protein Extracted from Bone Matrix with a Mixed Aqueous and Nonaqueous Solvent", Proc. Soc. Exp. Bio. and Med., 162, 48-53, (1979).
Termine et al., "Mineral and Collagen-Binding Proteins of Fetal Calf Bone", Journal of Biological Chemistry, No. 20, Issue of Oct. 25, pp. 10403-10408, 1981.
Takaoka et al., Purification of a Bone-Inducing Substance (Osteogenic Factor), from a Murine Osteosarcoma, Biomed. Res., 2(5), 466-471, (1981).
Takaoka et al., Clin. Orthop. & Rel. Res., 148, 274, (1980).
Takaoka et al., Clin. Orthop. & Rel. Res., 164, 265-270, (1982).
Mizutani and Urist, Clin. Ortho. Rel. Res., 171, 215-223, (1982).
Seyedin et al., Proc. Natl. Acad. Sci., 82, 2267-2271, (Apr. 1985).

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