Osteogenic devices

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424422, 424423, 424424, A61F 1300, A61F 200

Patent

active

058403256

ABSTRACT:
Disclosed are osteogenic devices comprising a matrix containing substantially pure mammalian osteogenic protein and methods of inducing endochondral bone growth in mammals. A partial amino acid sequence, amino acid composition, solubility properties, and various other data characterizing osteogenic protein are also disclosed, as well as a nucleic acid sequences encoding a consensus osteogenic protein.

REFERENCES:
patent: 4294753 (1981-10-01), Urist
patent: 4394370 (1983-07-01), Jefferies
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4455256 (1984-06-01), Urist
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4563489 (1986-01-01), Urist
patent: 4877864 (1989-10-01), Wang et al.
patent: 5011691 (1991-04-01), Oppermann et al.
patent: 5013649 (1991-05-01), Wang et al.
patent: 5108753 (1992-04-01), Kuberasampath et al.
patent: 5496552 (1996-03-01), Kuberasampath et al.
Canalis et al. (1980), "Stimulation of DNA and Collagen Synthesis by Autologous Growth Factor in Cultured Fetal Rat Calvaria," 210 Science 1021-1023.
Glowacki et al. (1981), "Application of the Biological Principle of Induced Osteogenesis For Craniofacial Defects," The Lancet 959-963.
Reddi, A.H. (1981), "Cell Biology and Biochemistry of Endochondral Bone Development," 1 Coll. Res. 209-226.
Sampath et al. (1981), "Dissociative Extraction and Reconstitution of Extracellular Matrix Compents Involved in Local Bone Differentiation," 78 Proc. Natl. Acad. Sci. USA 12:7599-7603.
Farley et al. (1982), "Human Skeletal Growth Factor: Characterization of the Mitogenic Effect on Bone Cells In Vitro," 21 Biochemistry 3508-3513.
Maugh, Thomas H. (1982) "Human Skeletal Growth Factor Isolated," 217 Science 819.
Sampath et al. (1983), "Homology of Bone-Inductive Proteins From Human, Monkey, Bovine, and Rat Extracellular Matrix," 80 Proc. Natl. Acad. Sci. USA 6591-6595.
Seyedin et al. (1983), "In Vitro Induction of Cartilage-Specific Macromolecules By A Bone Extract," 97 J. Cell Biol. 1950-1953.
Simpson, Ellen (1983), "Growth Factors Which Affect Bone," 9 Trends. Biochem. Sci. 527-530.
Urist et al. (1983), "Human Bone Morphogenetic Protein (hBMP)," 173 Proc. Soc. Exper. Biol. & Med. 194-199.
Urist et al. (1983), ".beta.-Tricalcium Phosphate Delivery System For Bone Morphogenetic Protein," 187 Clin. Orthop. Rel. Res. 277-280.
Urist et al. (1984), "Purification of Bovine Bone Morphogenetic protein by Hydroxyapatite Chromatography," 81 Proc. Natl. Acad. Sci. USA 371-375.
Centrella et al. (1985), "Transforming and Nontransforming Growth Factors Are Present in Medium Conditioned By Feral Rat Calvariae," 82 proc. Natl. Acad. Sci. USA 7335-7339.
Klausner, Arthur (1985), "Collagen Corp. Isolates Cartilage Inducers," 3 Biotechnology 567-568.
Olson et al. (1985), "Deglycosylation of Chondroitin Sulfate Proteoglycan by Hydrogen Fluoride in Pyuidine," 146 Anal. Biochem. 232-237.
Reddi, A.H. (1985), "Implant-Stimulated Interface Reactions During Collagenous Bone Matrix-Induced Bone Formation," 19 J. Biomed. Mat. Res. 233-239.
Sampath et al. (1985), "Role of Extracellular Matrix Components in Cartilage and Bone Induction," Allen R. Liss, Publ., NY, pp. 412-428.
Seyedin et al. (1985), "Purification and Characterization of Two Cartilage-Inducing Factors From Bovine Demineralized Bone," 82 Proc. Natl. Acad. Sci. USA 2267-2271.
Colowicki et al., "Preparation and Bioassay of Bone Morphogenetic Protein and polypeptide Fragments," 146 Meth. Enzymol. 294-312.
Padgett et al. (1987), "A Transcript From a Drosophila Pattern Gene Predicts A Protein Homologous To The Transforming Growth Factor-.beta.Family," Nature 323:81-84.
Sampath et al. (1987), "Isolation of Osteogenin, An Extracellular Matrix-Associated Bone-Inductive Protein, By Heparin Affinity Chromatography," 84 Proc. natl. Acad. Sci. USA 7109-7113.
Weeks et al. (1987), "A Maternal mRNA Localized To The Vegetal Hemisphere in Xenopus Eggs Codes For A Growth Factor Related to TGF-.beta.,"51 Cell 861-867.
LeGendre et al. (1988) "Direct Protein Microsequencing From Immobilon-P Transfer Membrane," 6 BioTechniques 2:154-159.
Wang et al. (1988), "Purification and Characterization of Other Distinct Bone-Inducing Factors," 85 Proc. Natl. Acad. Sci. USA 9484-9488.
Wang et al. (1988), "Purification and Characterization of Cartilage and Bone Inducing Factors," Calcified Tissue International 42 (Suppl.): A37 (Abstr. No. 146).
Wozney et al. (1988), "Identification Through Molecular Cloning of Factors Involved In Vivo Cartilage Formation," Calcified Tissue International 42 (Suppl.): A37 (Abstr. No. 147).
Wozney et al. (1988), "Novel Regulators of Bone Formation: Molecular Clones and Activities," 242 Science 1528-1534.
Lyons et al. (1989), "VGR-1, A Mammalian Gene Related to Xenopus Vg-1, is a Member of The Transforming Growth Factor .beta. Gene Superfamily," 86 Proc. Natl. Acad. Sci. USA 4554-4558.
Wang et al. (1990), "Recombinant Human Bone Morphogenetic Protein Induces Bone Formation," 87 Proc. Natl. Acad. Sci. USA 2220-224.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Osteogenic devices does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Osteogenic devices, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Osteogenic devices will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1699367

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.