Osteogenic devices

Details Osteogenic devices Osteogenic devices

1989-02-23

1991-04-30

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424426, 514 2, 514 21, 530350, 530395, 530840, C07K 1300, C07K 1500, A61K 3700, C12P 2100

Patent

active

050116916

ABSTRACT:
Disclosed are (1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; (2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, (3) methods of producing osteogenic proteins using recombinant DNA technology, and (4) osteogenically and chondrogenically active synthetic protein constructs.

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Padgett et al., Nature 325:81-84 (1987).
Wang et al., Proc. Natl. Acad. Sci. U.S.A., vol. 87, pp. 2220-2224, Mar., 1990 Biochemistry; Recombinant Human Bone Morphogenetic . . . .

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