Osteogenesis promotion with use of vitamin D derivatives

Details Osteogenesis promotion with use of vitamin D derivatives Osteogenesis promotion with use of vitamin D derivatives

1990-02-27

1991-10-01

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

A61K 3159

Patent

active

050534017

ABSTRACT:
An osteogenesis promotion with use of a vitamin D derivative of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents a hydrogen atom or a hydroxyl group; and R.sub.4 is a hydrogen atom or a lower alkyl group having 4-6 carbon atoms that may or may not be substituted by a hydroxyl group, are disclosed. A pharmaceutical composition comprising the above derivatives is useful as a therapeutic agent for osteoporosis.

REFERENCES:
patent: 4891364 (1990-01-01), Kubodera et al.
Holick et al., C.A. 82:110660r (1975).
Kubodera et al., C.A. 106:84945e (1987).
Abe et al., C.A. 108:88191v (1988).
Abe et al., C.A. 110:69959b (1989).
Valaja et al., C.A. 113:109898b (1990).

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