Osteoclast transporter

Details Osteoclast transporter Osteoclast transporter

1996-05-09

1999-10-26

Degen, Nancy

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 235, 536 241, C12N 500, C07H 2104

Patent

active

059727020

ABSTRACT:
The invention pertains to osteoclast transporter proteins and genes encoding such proteins, as well as fragments and biologically functional variants thereof. The invention also pertains to therapeutics and diagnostics involving the foregoing proteins and genes and agents that bind the foregoing proteins and genes, to influence osteoclast activity and bone remodeling.

REFERENCES:
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Evans et al. Possible orthopaedic application of gene therapy. J. Bone and Joint Surg. vol. 77-A(7):1103-1114, Jul. 1995.
Turner et al. Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125fak binding region. J. Cell Sci. vol. 107:1582-1591, Jul. 1994.
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Grundemann, et al., Nature 372:549-552, 1994.
Beier et al., The American Journal of Human Genetics 59:A280 (1996).
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