Osteoclast growth regulating factors and antibodies

Details Osteoclast growth regulating factors and antibodies Osteoclast growth regulating factors and antibodies

1994-07-25

1997-02-04

Budens, Robert D.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4241381, 4241451, 4241551, 4241741, 4241781, 4241851, 4241981, 435 702, 4351722, 530326, 53038824, 5303891, 530413, C12N 1513, A61K 39395, C07K 1400, C12P 2102

Patent

active

055997082

ABSTRACT:
The present invention relates to a novel osteoclast growth regulatory factor, hereinafter referred to as "osteoclastpoietic factor (OPF)," which stimulates the formation of osteoclast bone cells, a process of preparing same, therapeutic and diagnostic uses thereof, antibodies to and antagonists of OPF, and assays for OPF, all of which relate to the development of therapeutics for the prevention and treatment of diseases involving bone tissue, for example, osteoporosis, Paget's disease and osteopetrosis.

REFERENCES:
patent: 5169837 (1992-12-01), Lagarde et al.
Rudinger Pepticle Harmones ed Parsons Univ. Park Press 1976 pp. 1-7.
Yoneda et al Oral Surg Oral Med Oral Pathology 68:604-611 1989.
Mundy Trends Endo. Metab. 1:307-311 1990.
Yoneda J. Clin. Oncol 9:468-477 1991.
Josse, et al J. Clin Invest G7:1472-1481 1981.
Waldmann Science 252:1657-1662 1991.
Current Protocols in Molecular Biology 1987 Wiley & Sones Chapters 10 & 11.
Yoneda et al Cancer Research 51:2438-2443 1991.

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