Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-11-21
1998-10-13
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 4352523, 435325, 536 235, 536 243, C12N 1552
Patent
active
058210849
ABSTRACT:
A previously undiscovered transmembrane protein tyrosine phosphatase expressed only in bone and testis, osteotesticular protein tyrosine phosphatase (OST-PTP), has been identified, cloned, sequenced, expressed and subjected to enzymatic analysis. Also, a truncated osteoblast specific form (OST) containing the OST-PTP receptor but lacking the catalytic domain was identified and characterized. Based on the unique expression pattern of OST-PTP and OST during osteogenesis, assays can be used to screen for abnormal bone growth patterns and metabolic bone diseases. Moreover, this novel protein provides a specific target for use in conventional and gene therapies directed at treatment of osteoporosis, osteopetrosis and other bone metabolic disorders.
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Davis Alan Robert
Dixon Jack Edward
Mauro Laura Jeanne
Olmsted Elizabeth Ann
American Home Products Corporation
Brown Karen E.
The Regents of the University of Michigan
Ulm John
LandOfFree
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