Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-09-30
2000-06-13
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435326, 435810, 5303881, 5303882, 53038885, 5303911, 5303913, 5303917, G01N 3353, C12N 512, A61K 3514
Patent
active
060748338
ABSTRACT:
Monoclonal antibodies (MAb) are provided which have binding specificity to an antigen expressed on osteogenic and fibroblastic cells (OFA) and are capable of binding to osteogenic and fibroblastic cells at a substantially higher extent as compared to their binding to skin fibroblasts and stromal adipocytes. Also provided is a novel osteogenic and fibroblastic antigen (OFA) which is expressed on osteogenic and fibroblastic cells at a higher level than its expression in skin fibroblasts and stromal adipocytes having a molecular weight of about 80 kD as determined by western blotting or immunoprecipitation. The OFA and anti-OFA-MAbs are useful in the diagnosis and treatment of various hone related conditions.
REFERENCES:
Burgess et al ( J. Cell Biol., 111: 2129-2138), 1990.
Lazar et al ( Mol. & Cell Biol., 8: 1247-1252), 1988.
Tao et al ( J. Immunol., 143: 2595-2601, 1989.
Shull et al ( PNAS, 86: 5405-5409), 1989.
Isacke et al ( Mol. & Cell Biol., 10: 2606-2618), 1990.
Benayahu et al ( J. Bone & Min. Res. 10: 1496-1503, 1995.
Johnstone & Thorpe ( Immunochemistry in Practice, Blackwell Scientific Pub., Oxford 1987, pp. 49-50).
Benayahu Dafna
Wientroub Shlomo
Hutzell Paula K.
Nath Gary M.
Ramot University Authority
Ungar Susan
Yarnell Scott F.
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