Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-09-08
1997-08-12
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 435348, 435419, 435366, 536 231, 530350, C12P 2106, C12N 500, C12N 1500, C07H 1700
Patent
active
056564511
ABSTRACT:
Methods and compositions for the prevention, treatment and diagnosis of Lyme disease. Novel B. burgdorferi polypeptides, serotypic variants thereof, fragments thereof and derivatives thereof. Fusion proteins and multimeric proteins comprising same. Multicomponent vaccines comprising novel B. burgdorferi polypeptides in addition to other immunogenic B. burgdorferi polypeptides. DNA sequences, recombinant DNA molecules and transformed host cells useful in the compositions and methods. Antibodies directed against the novel B. burgdorferi polypeptides, and diagnostic kits comprising the polypeptides or antibodies.
REFERENCES:
patent: 4721617 (1988-01-01), Johnson
patent: 4772464 (1988-09-01), Rutherford et al.
patent: 5178859 (1993-01-01), Simon et al.
patent: 5217872 (1993-06-01), Dorward et al.
Probert et al 1994 Infect. Immun. 62: 1920-1926.
Coleman et al 1994 Infect. Immun. 62: 303-307.
Fikrig et al. 1992 J.Immunol 148: 2256-2260.
Wilske et al 1992 Res Microbiol 143:583-596.
Wilske et al 1993 Infect Immun 61: 2182-2191.
Bergstrom et al 1989 Abstract Mol. Microbiol. 3: 479-486.
Lam et al 1994 Infect. Immun. 62: 290-298.
A.G. Barbour, et al., "Heterogeneity of Major Proteins in Lyme Disease Borreliae: A Molecular Analysis of North American and European Isolates", J. Infect. Dis., 152, pp. 478-484 (1985).
G. Beck, et al., "Chemical and Biologic Characterization of a Lipopolysaccharide Extracted From the Lyme Disease Sprirochete (Borrelia burgdorferi)", J. Infect. Dis., 152, pp. 108-117 (1985).
M. Brandt et al., "Immunogenic Integral Membrane Proteins of Borrelia burgdorferi Are Lipoproteins", Infect. Immun., 58, pp. 983-991 (1990).
J.L. Coleman and J.L. Benach, "Isolation of Antigenic Components from the Lyme Disease Spirochete: Their Role in Early Diagnosis", J. Infect. Dis., 155, pp. 756-765 (1987).
J.E. Craft et al., "Antigens of Borrelia burgdorferi Recognized during Lyme Disease", J. Clin. Invest., 78, pp. 934-936 (1986).
M.S. deSouza, et al., "Long-Term Study of Cell-Mediated Responses to Borrelia burgdorferi in the Laboratory Mouse", Infect. Immun., 61, pp. 1814-1822 (1993).
EMBL Database, entry BBLA7 Accession No. X70826; 8 Feb. 1993.
L.F. Erdile, et al., "Role of Attached Lipid in Immunogenicity of Borrelia burgdorferi OspA", Infect. Immun., 61, pp. 81-90 (1993).
E. Fikrig et al., "Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA", Science, 250, pp. 553-556 (1990).
E. Fikrig et al., "Elimination of Borrelia burgdorferi From Vector Ticks Feeding on OspA-Immunized Mice", Proc. Natl. Acad. Sci. USA, 89, pp. 5418-5421 (1992).
F. Fuchs et al., "Molecular Analysis and Expression of a Borrelia burgdorferi gene encoding a 22kDa protein (pC) in Escherichia coli", Mol. Micro., 6, pp. 503-509 (1992).
R.L. Grodzicki and A.C. Steere, "Comparison of Immunoblotting and Indirect Enzyme-Linked Immunosorbent Assay Using Different Antigen Preparations for Diagnosing Early Lyme Disease", J. Infect. Dis., 157, pp. 790-797, (1988).
T.R. Howe et al., "A Single Recombinant Plasmid Expressing Two Major Outer Surface Proteins of the Lyme Disease Spirochete", Science, 227, pp. 645-646 (1985).
W. Jiang, et al., "Cross-Antigenicity Between The Major Surface Proteins (OspA and OspB) And Other Proteins Of Borrelia burgdorferi", J. Immunol., 144, pp. 284-289 (1990).
R.C. Johnson et al., "Active Immunization of Hamsters against Experimental Infection with Borrelia burgdorferi", Infect. Immun., 54, pp. 897-898 (1986).
R.C. Johnson, et al., "Passive Immunization of Hamsters against Experimental Infection with the Lyme Disease Spirochete", Infect. Immun., 53, pp. 713-714 (1986).
M.D. Kramer, et al., "Characterization of Borrelia burgdorferi Associated Antigens by Monoclonal Antibodies" Immunobiol., 181, pp. 357-366 (1990).
M.D. Kramer, et al., "Die Borrelia-burgdorferi-Infektion", Ubersichten, 41, pp. 648-657 (1990).
M.D. Kramer et al., "Characterization of Borrelia burgdorferi Associated Antigens by Monoclonal Antibodies", Immunobiol., 181, pp. 357-366 (1990).
R.S. Lane and J.A. Pascocello, "Antigenic Characteristics of Borrelia burgdorferi Isolates from Ixodid Ticks in California," J. Clin. Microbiol., 27, pp. 2344-2349 (1989).
R.B. LaFebvre, et al., "Characterization of Borrelia burgdorferi Isolates by Restriction Endonuclease Analysis and DNA Hybridization", J. Clin. Microbiol., 27, pp. 636-639 (1989).
B.J. Luft et al., "Biochemical and Immunological Characterization of the Surface Proteins of Borrelia burgdorferi", Infect. Immun., 57, pp. 3637-3645 (1989).
L.A. Magnarelli, et al., "Cross-Reactivity in Serological Tests for Lyme Disease and Other Spirochetal Infections", J. Infect. Dis., 156, pp. 183-188 (1987).
S.J. Norris et al., "Low-Passage-Associated Proteins of Borrelia burgdorferi B31: Characterization and Molecular Cloning of OspD, a Surface-Exposed, Plasmid-Encoded Lipoprotein, Infect. Immun.," 60, pp. 4662-4672 (1992).
V. Preac-Mursic, et al., "Active Immunization with pC Protein of Borrelia burgdorferi Protects Gerbils against B. burgdorferi Infection", Infection, 20, pp. 342-348 (1992).
A. Sadziene, et al., "Antibody-resistant Mutants of Borrelia burgdorferi: In Vitro Selection and Characterization", J. Exper. Med., 176, pp. 799-809 (1992).
U.E. Schaible, et al., "Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice", Proc. Natl. Acad. Sci. USA, 87, pp. 3768-3772 (1990).
U.E. Schaible, et al., "A Mouse Model for Borrelia burgdorferi Infection: Pathogenesis, Immune Response and Protection", Behring Inst. Mitt., 88, pp. 59-67 (1991).
U.E. Schaible, et al., "Demonstration of Antigen-Specific T Cells and Histopathological Alterations in Mice Experimentally Inoculated with Borrelia burgdorferi", Infect. Immun., 57, pp. 41-47 (1989).
J.L. Schmitz, et al., "Passive Immunication Prevents Induction of Lyme Arthritis in LSH Hamsters", Infect. Immun., 58, pp. 144-148 (1990).
T.G. Schwan et al., "Changes in Infectivity and Plasmid Profile of the Lyme Disease Spirochete, Borrelia burgdorferi, as a Result of In Vitro Cultivation", Infect. Immun., 56, pp. 1831-1836 (1988).
J.E. Sears, et al., "Molecular Mapping Of Osp-A Mediated Immunity Against Borrelia burgdorferi, The Agent of Lyme Disease", J. Immunol., 147, pp. 1995-2000 (1991).
M.M. Simon, et al., A Mouse Model for Borrelia burgdorferi Infection: "Approach To A Vaccine Against Lyme Disease," Immunol. Today, 12, pp. 11-16 (1991).
W.J. Simpson et al., "Reactivity of Human Lyme Borreliosis Sera with a 39-Kilodalton Antigen Specific to Borrelia burgdorferi", J. Clin. Microbiol., 28, pp. 1329-1337 (1990).
D.J. Volkman et al., "Characterization Of An Immunoreactive 93-k-Da Core Protein Of Borrelia burgdorferi With A Human IgG Monoclonal Antibody", J. Immunol., 146, pp. 3177-3182 (1991).
T.A. Waldmann, "Monoclonal Antibodies in Diagnosis and Therapy", Science, 252, pp. 1657-1662 (1991).
R. Wallich et al., "The Borrelia burgdorferi Flagellum-Associated 41-Kilodalton Antigen (Flagellin): Molecular Cloning, Expression, and Amplification of the Gene", Infect. Immun., 58, pp. 1711-1719 (1990).
B. Wilske, et al., "Antigenic Variability of Borrelia burgdorferi", Annals of N.Y. Acad. of Sciences, pp. 126-143.
B. Wilske et al., "Immunochemical Analysis of the Immune Response in Late Manifestations of Lyme Borreliosis", Zbl. Bakt. Hyg., 267, pp. 549-559 (1988).
B. Wilske, et al., "Immunochemical and Immunlogical Analysis of European Borrelia burgdorferi Strains", Zbl. Bakt. Hyg., 263, pp. 92-102 (1986).
Barthold Stephen W.
Fikrig Erol
Flavell Richard A.
Kantor Fred S.
Lam Tuan T.
Carlson K. Cochrane
Gunnison, Esq. Jane T.
Haley, Jr. Esq. James F.
Wax Robert A.
Yale University
LandOfFree
OspE, OspF, and S1 polypeptides in borrelia burgdorferi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with OspE, OspF, and S1 polypeptides in borrelia burgdorferi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and OspE, OspF, and S1 polypeptides in borrelia burgdorferi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-159384