Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1992-02-18
1993-05-11
Rosenbaum, C. Fred
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
604131, 604135, 6048901, A61K 922
Patent
active
052097463
ABSTRACT:
Osmotically driven delivery capsules which include a beneficial agent and a water absorptive osmotic engine in separate compartments separated by a movable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a series of stops along the inner wall of the capsule which obstruct the movement of the partition but which are overcome in succession as the osmotic pressure rises above a threshold level. The number of stops and their placement longitudinally along the length of the capsule establish the number and frequency of the pulses, and the configuration of the partition controls the pulse intensity.
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Baile Clifton A.
Balaban Stephen M.
Pike James B.
Smith Jonathan P.
ALZA Corporation
Larson Jacqueline S.
Rosenbaum C. Fred
Sabatine Paul L.
Smith Chalin
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