Osmotically dependent vesicles

Details Osmotically dependent vesicles Osmotically dependent vesicles

1989-01-18

1991-09-17

Page, Thurman

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

436829, 264 41, 264 43, 424 88, 514885, A61K 3722, A61K 3900, B01J 1302

Patent

active

050493922

ABSTRACT:
Osmotically derived liposomal vesicles loaded with an active agent are disclosed. Liposomes, including an entrapped osmotic agent, are contacted one or more times with a washing solution which is hypotonic to the entrapped osmotic agent and which contains active agent. The entrapped osmotic agent in the liposome and the active agent in the washing solution are each present in concentrations causing the liposomes to swell, rupture under osmotic pressure, spill osmotic agent into the washing solution and re-form to encapsulate active agent.

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