Osmotically controlled fermentation process for the preparation

Details Osmotically controlled fermentation process for the preparation Osmotically controlled fermentation process for the preparation

1997-09-05

2000-10-10

Prats, Francisco

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 72, 435 84, 435100, 435101, C12P 1928

Patent

active

061300721

ABSTRACT:
The invention relates to a novel fermentative process for the preparation of acarbose. By monitoring and controlling the osmolality in the fermentation solution, a substantial improvement in yield from the fermentation is achieved.

REFERENCES:
patent: 4062950 (1977-12-01), Frommer et al.
Pelczar et al, Elements of Microbiology, McGraw-Hill, New York, pp. 91-107, 1981.
Crueger et al, Biotechnology: A Textbook of Industrial Microbiology, 2nd. Ed, 1989, pp. 64-70.
The Merck Index, 11.sup.th Ed. p. 4, 1989.
Bodeker, B.G.D.: "Bioprocess technologies depending on the molecular structure of pharmaceutical products", Bd. 50, Sept. 1996, pp. 412-413.
Goeke, K.: "Enzymatische Untersuchungen zum Zuckerstoffwechsel und zur Biosynthesis des alpha-glucosidase-inhibitors Acrabose bei Actinoplanes sp.", 1986, pp. 15-23, and 77-87.

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