Osmotic system having laminated wall comprising semipermeable la

Details Osmotic system having laminated wall comprising semipermeable la Osmotic system having laminated wall comprising semipermeable la

1977-04-07

1979-07-10

Padgett, Benjamin R.

Surgery

Respiratory method or device

Ozone or ion generation

128272, 424 19, 424 20, 424 21, 424 22, A61M 3100

Patent

active

041604520

ABSTRACT:
An osmotic therapeutic system for delivering a beneficial drug is disclosed. The system comprises a drug delivery module which module comprises a rate controlling laminated wall surrounding a reservoir and has a portal for delivering drug from the system. The laminated wall comprises a semipermeable lamina in laminar arrangement with a microporous lamina to provide a wall that is permeable to an external fluid, impermeable to drug and maintains its integrity during the delivery of drug. The reservoir contains a drug, or a mixture of drug and solute which drug or solute is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid. In operation, drug is released from the system by fluid being imbibed through the wall into the reservoir at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall thereby producing a solution of drug, or a solution of solute containing drug which solution is released through the portal at a controlled rate over a prolonged period of time.

REFERENCES:
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patent: 3948254 (1976-04-01), Zaffaroni
patent: 3961628 (1976-06-01), Arnold
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patent: 3981303 (1976-09-01), Higuchi et al.
patent: 4008719 (1977-02-01), Theeuwes et al.
patent: 4014334 (1977-03-01), Theeuwes et al.
patent: 4036227 (1977-07-01), Zaffaroni et al.

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