Surgery – Controlled release therapeutic device or system
Patent
1997-11-24
1999-11-09
Coggins, Wynn Wood
Surgery
Controlled release therapeutic device or system
424422, A61K 922
Patent
active
059805099
ABSTRACT:
A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may be adapted for ultrasonic welding to the first wall section and may maintain the beneficial agent in contact with an exit. The compartment comprises a beneficial agent and an expandable driving member. The delivery system comprises an exit for delivering the beneficial agent to the animal. The exit may compensate for slight variations in the efflux rate of the beneficial agent and maintain a sufficient velocity or efflux rate of beneficial agent outward from the device while minimizing diffusion of fluids from the external environment back into the device.
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Cortese Richard
Eckenhoff James B.
Magruder Judy A.
Peery John R.
Pike James B.
ALZA Corporation
Clarke Pauline A.
Coggins Wynn Wood
Dillahunty Mary Ann
Nguyen A. T.
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