Surgery – Respiratory method or device – Ozone or ion generation
Patent
1977-03-09
1979-03-06
Padgett, Benjamin R.
Surgery
Respiratory method or device
Ozone or ion generation
A61M 3100, A61M 3700
Patent
active
041425260
ABSTRACT:
An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of a pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid, or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.
REFERENCES:
patent: 3625214 (1970-05-01), Higuchi
patent: 3630200 (1971-12-01), Higuchi
patent: 3845770 (1974-11-01), Theeuwes et al.
patent: 3867519 (1975-02-01), Michaels
patent: 3916899 (1975-11-01), Theeuwes et al.
patent: 3993071 (1976-11-01), Higuchi et al.
patent: 4036227 (1977-07-01), Zaffaroni et al.
Michaels Alan S.
Theeuwes Felix
Zaffaroni Alejandro
ALZA Corporation
Ciotti Thomas E.
Mandell Edward L.
Nucker Christine M.
Padgett Benjamin R.
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