Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1991-12-04
1994-01-18
Green, Randall L.
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
604131, 6048901, A61M 514
Patent
active
052796086
ABSTRACT:
An osmotic pump comprises a housing (2) within which is a delivery chamber (5) separated from an osmotic salt chamber (7) by impermeable moveable pressure responsive means such as a piston (6) or a flexible membrane. The osmotic salt chamber (7) is separated from a source of osmotic fluid, e.g. an osmotic fluid chamber (12), by a semipermeable membrane (96,36), optionally mounted in a piston (9,23). A fluid barrier isolates the osmotic salt chamber (7) from the source of osmotic fluid for storage of the pump, and may be inactivated when the pump is to be used. The fluid barrier may be a foil sheet (10), inactivatable by rupture, or a piston and a fluid bypass arrangement (21,23). Activation of the osmotic pump may be effected in some embodiments by loading the discharge chamber (5) with the agent to be delivered and in other embodiments by movement of a plunger (16), under manual control or, if the plunger is pre-biassed, by release of a locking means (18) which holds it in position.
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Clarke Rob
Green Randall L.
Societe de Conseils de Recherches et d'Applications Scientifique
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