Surgery – Controlled release therapeutic device or system
Patent
1982-03-22
1984-06-19
Padgett, Benjamin R.
Surgery
Controlled release therapeutic device or system
A61M 3100
Patent
active
044551436
ABSTRACT:
An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a semipermeable wall surrounding a lumen divided into a first compartment containing a drug that is separated from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug from the second compartment. In operation, drug is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug in each compartment thereby producing in each compartment a solution containing drug that is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.
REFERENCES:
patent: 3845770 (1974-11-01), Theeuwes et al.
patent: 3916899 (1975-11-01), Theeuwes et al.
patent: 4111202 (1978-09-01), Theeuwes
patent: 4210139 (1980-07-01), Higuchi
patent: 4298003 (1981-11-01), Theeuwes et al.
Barclay Brian
Cortese Richard
Theeuwes Felix
ALZA Corporation
Mandell Edward L.
Padgett Benjamin R.
Sabatine Paul L.
Stone Steven F.
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