Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Reexamination Certificate
2007-06-26
2007-06-26
Kennedy, Sharon E. (Department: 1615)
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
C424S422000
Reexamination Certificate
active
11353842
ABSTRACT:
An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the piston, a protein or peptide, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmopolymer from the protein or peptide. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.
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Theeuwes et al., “Principles of the Design and Operation of Generic Osmotic Pumps for the Delivery of Semisolid or Liquid Drug Formulations,” Annals of Biomedical Engineering 4 (1970), pp. 343-353.
U.S. Appl. No. 08/595,761, entitled “Sustained Delivery of an Active Agent Using an Implantable System,” 23 pages.
Dennis, legal representative Bonnie Burdett
Theeuwes Felix
Alza Corporation
Kennedy Sharon E.
TraskBritt
LandOfFree
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