Osmotic delivery system having space efficient piston

Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system

Reexamination Certificate

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C424S422000

Reexamination Certificate

active

06997922

ABSTRACT:
An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the piston, a beneficial agent, and an osmopolymer including a tablet. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmopolymer from the beneficial agent. The piston has a recess that receives at least a portion of the osmopolymer. The osmopolymer imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.

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Theeuwes et al., “Principles of the Design and Operation of Generic Osmotic Pumps for the Delivery of Semisolid or Liquid Drug Formulations”, Annals of Biomedical Engineering 4 (1970), pp. 343-353.
U.S. Appl. No. 08/595,761, Entitled “Sustained Delivery of an Active Agent Using an Implantable System”, 23 pages, without figures or claims.

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