Osmosensing histidine kinases

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

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435 6, 435 691, 435194, 4352541, 43525411, 43525421, 43525422, 4352543, 4352544, 4353201, 536 231, 536 232, 536 237, 536 2374, C12N 121

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059393068

ABSTRACT:
The present invention relates to histidine kinases, including osmosensing fungal histidine kinases. In particular, the present invention provides amino acid and nucleic acid sequences of fungal histidine kinases from organisms such as Candida (e.g., C. albicans) and Neurospora (e.g., N. crassa). The present invention further provides compositions and methods for the development of antifungal compounds.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
Anaissie, "Opportunistic Mycoses in the Immunocompromised Host: Experience
Zinsser 'Microbiology, Chapter 87, "Opportunistic Mycoses," W.K. Joklik, et
Walsh and Dixon, "Spectrum of Mycoses," in Medical Microbiology, 4th ed, Baron (ed.) University of Texas Medical Branch, Galveston, TX, pp. 919-925
Chandler, Mycotic Diseases, 8 Candidiasis, Color Atlas and Text of
Meunier et al., "Fungal Infections in Immunocompromised Hosts: Candidemia
Loose et al., "Distribution of a Corticosteroid-binding Protein in Candida
Loose and Feldman, "Characterization of a Unique Corticosterone-binding
Cole, "Basic Biology of Fungi," in Medical Microbiology, 4th ed., Baron (ed.), University of Texas Medical Branch, Galveston, TX, pp. 903-911
McGinnis and Tyring, "Introduction to Mycology," in Medical Microbiology, 4th ed., Baron (ed.), University to Texas Medical Branch, Galveston, TX,
Dixon and Walsh, "Antifungal Agents," in Medical Microbiology, 4th ed., Baron (ed.), University of Texas Medical Branch, Galveston, TX, pp.
Gooday, "Chitin metabolism: A target for antifungal and antiparasitic drugs," Molecular Aspects of Chemotherapy, E. Borowski (ed.), Pergamon
Georgopapadakou and Tkacz, "The fungal cell wall as a drug target," Trends
Schmatz et al., "Treatment of Pneumocystis carinii pneumonia with 1,3-.beta.-glucan synthesis inhibitors," Proc. Natl. Acad. Sci.
Alex and Simon, "Protein histidine kinases and signal transduction in
Swanson et al., "Histidine and aspartate phosphorylation: two-component systems and the limits of homology," Trends Biochem. Sci. 19: 485-490
Parkinson et al., "Communication Modules in Bacterial Singaling Proteins,"
Chang et al., "Arabidopsis Ethylene-Response Gene ETR1: Similarity of
Ota and Varshavsky, "A Yeast Protein Similar to Bacterial Two-Component
Maeda et al., "A two-component system that regulates an osmosensing MAP
Schuster et al., "The hybrid histidine kinase DokA is part of the osmotic
Wang et al., "A two-component histidine kinase gene that functions in
Kakimoto, "CK11, a Histidine Kinase Homolog Implicated in Cytokinin Signal
Alex et al., "Hyphal development in Neurospora crassa: Involvement of a two-component histidine kinase," Proc. Natl. Acad. Sci. 93:3416-3421
Morgan et al., "Two-component signal-transduction systems in budding yeast
Posas et al., "Yeast HOGI MAP Kinase Cascade Is Regulated by a Multistep Phosphorelay Mechanism in the SLN1-YPD1-SSK1 `Two-Component` Osmosensor,"
Appleby et al., "Signal Transduction via the Multi-Step Phosphorelay: Not
Burbulys et al., "Initiation of Sporulation in B. subtilis is Controlled by
Uhl and Miller, "Integration of multiple domains in a two-component sensor protein: the Bordetella pertussis BvgAS phosphorelay," EMBO J.
Brown et al., "Yeast Skn7p functions in a eukaryotic two-component
Brown et al., "SKN7, a Yeast Multicopy Suppressor of a Mutation Affecting Cell Wall .beta.-Glucan Assembly, Encodes a Product with Domains Homologous to Prokaryotic Two-Component Regulators and to Heat Shock
Krems et al., "The response regulator-like protein Pos9/Skn7 of Saccharomyces cerevisiae is involved in oxidative stress resistance,"
Page et al., "Identification of ASK10 as a Multicopy Activator of Skn7p-dependent Transcription of a HIS3 Reporter Gene," Yeast 12:267-272
Springer, "Genetic Control of Fungal Differentiation: The Three Sporulation
Vollmer and Yanofsky, "Efficient cloning of genes of Neurospora crassa,"
Dieffenbach and Dveksler, PCR Primer, a Laboratory Manual, Cold Spring
Mullis et al., "Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction," Cold Spring Harbor Symposia, vol. LI, pp.
Selitrennikoff et al., "Formation and Regeneration of Protoplasts Derived from a Temperature-Sensitive Osmotic Strain of Neurospora crassa," Exp.
Davis and deSerres, "Genetic and Microbiological Research Techniques for
Grindle and Dolderson, "Notes and Brief Articles: Effects of a Modifier Gene on the Phenotype of a Dicarboximide-Resistant Mutant of Neurospora
Sambrook et al. (eds.), Molecular Cloning: A Laboratory Manual, Cold Spring
Orbach et al., "Cloning and Characterization of the Gene for .beta.-Tubulin from a Benomyl-Resistant Mutant of Neurospora crassa and Its Use as a
Selitrennikoff and Sachs, "Lipofectin increases the efficiency of DNA-mediated transformation of Neurospora crassa," Fungal Genet. Newsl.
White and Woodward, "A simple method for making disposable race tubes,"
Altschul et al., "Basic Locl Alignment Search Tool," J. Mol. Biol.
Bairoch, "Teh PROSITE dictionary of sites and patterns in proteins, its
Bruchez et al., "Regulatory sequences in the transcription of Neurospora crassa genes: CAAT box, TATA box, Introns, Poly(A) tail formation
Nagasawa et al., "A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive
Liao et al., "Molecular Characterization of Two Gene Loci Required for Production of the Key Pathogenicity Factor Pectate Lyase in Pseudomonas
Corbell and Loper, "A Global Regulator of Secondary Metabolite Production
Perego and Hoch, "Protein aspartate phosphatases control the output of
Perkins et al., "Chromosomal Loci of Neurospora crassa ," Microbiol. Rev.
von Heijne, "A new method for predicting signal sequence cleavage sites,"
Larsson et al.,"A gene encoding sn-glycerol 3-phosphate dehydrogenase (NAD+) complements an osmosensitive mutant of Saccharomyces cerevisiae,"
Aatsinki et al., "A Coupled One-Step Reverse Transcription PCR Procedure for Generation of Full-Length Open Reading Frames," BioTechn. 16:282-288
Dale et al., "A Rapid Single-Stranded Cloning Strategy for Producing a Sequential Series of Overlapping Clones for Use in DNA Sequencing: Application to Sequencing the Corn Mitochondrial 18 S rDNA," Plasmid
Orbach et al., "The Neurospora crassa arg-2 Locus," J. Biol. Chem.
Okamoto et al., "Nit-3, the structural gene of nitrate reductase in Neurospora crassa: nucleotide sequence and regulation of mRNA synthesis
Bruchez et al., "Regulatory sequences involved in the translation of Neurospora crassa mRNA: Kozak sequences and stop codons," Fungal Genet.
Lupas et al., "Predicting Colied Coils from Protein Sequences," Science
Yao and Spudich, "Primary structure of an archaebacterial transducer, a methyl-accepting protein associated with sensory rhodopsin I," Proc. Natl.
Reinert et al., "Genetic Regulation of the qa Gene Cluster of Neurospora crassa: Induction of qa Messenger Ribonucleic Acid and Dependency on qa-1
Case et al., "Efficient transformation of Neurospora crassa by utlizing
Metzenberg, "An alternate way of collecting, storing and dissecting
Selker, "Premeiotic Instability of Repeated Sequences in Neurospora
Manning and Mitchell, "Strain Variation and Morphogenesis of Yeast-and Mycelial-Phase Candida Albicans in Low-Sulfate, Synthetic Medium," J.
Scherer and Stevens, "A Candida albicans dispersed, repeated gene family and its epidemiologic applications," Proc. Natl. Acad. Sci. 85:1452-1456
Moreno et al., "Molecular Genetic Analysis of Fission Yeast
Vieira and Messing, "New pUC-derived cloning vectors with different
Hughes, "Histidine kinases hog the limelight," Nature 369:187-188 (1994), reports on the conclusions drawn from the analysis of Maeda et al. Maeda
Wingrove and Gober, "Identification of an Asymmetrically Localized Sensor Histidine Kinase Responsible for Temporally and Spatially Regulated Transcription," Science 274:597-601 (1996).
Huang et al., "Purification of a Protein Histidine Kinase from the Yeast Saccharomyces cerevisiae," The American Society for Biochemistry and Molecular Biology 266(14):9023-

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