Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Reexamination Certificate
2005-06-27
2010-06-29
Lukton, David (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
C514S012200
Reexamination Certificate
active
07745575
ABSTRACT:
OsK1 is a 38-residue peptide with 3 disulphide bridges and is found in the venom of the scorpionOrthochirus scrobiculosus. It is potently active on voltage-gated K+channels Kv1.1, Kv1.2 and Kv1.3, and moderately active on the type 1 intermediate-conductance Cat2+-activated channel KCa3.1. Derivatives of OsK1, particularly involving truncation or point mutations, have been developed to enhance the activity against and selectivity for the Kv1.3 channel. This renders the derivatives likely candidates for the treatment of autoimmune diseases, including multiple sclerosis. Such use may be alone or in combination therapy with maurotoxin, another scorpion toxin.
REFERENCES:
patent: 2004/0039167 (2004-02-01), Sabatier et al.
patent: 2007/0071764 (2007-03-01), Sullivan et al.
English Abstract of WO 99/018123, issued 1999.
Jaravine Victor et al., “Three-dimensional structure of toxin OSK1 from Orthochirus scrobiculosus scorpion venom”, Biochemistry, vol. 36, No. 6, pp. 1223-1232 (1997).
Huys, Isabelle et al., “Evidence for a function-specific mutation in the neurotoxin, parabutoxin 3”, European Journal of Neuroscience, vol. 17, No. 9, pp. 1786-1792 (2003).
Lanigan, M. D. et al., “Designed peptide analogues of the potassium channel blocker ShK toxin,” Biochemistry, American Chemical Society, vol. 40, No. 51 (2001).
Mouhat, Stephanie et al., “K+ channel types targeted by synthetic OSK1, a toxin fromOrthochirus scrobiculosusscorpion venom,” Biochemical Journal, vol. 385, No. part 1, pp. 95-104 (2005).
Tytgat et al., “A unified nomenclature for short-chain peptides isolated from scorpion venoms: a-KTx molecular subfamilies,” Trends Pharmacol. Sci., 20(11), pp. 444-447 (1999).
de Rouge Bonabes Olivier
Mouhat Stephanie
Sabatier Jean-Marc
Cellpep Pharma Inc.
Clark & Elbing LLP
Lukton David
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