Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2011-02-22
2011-02-22
Monshipouri, Maryam (Department: 1656)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C530S357000
Reexamination Certificate
active
07892572
ABSTRACT:
The invention provides a biocompatible material derived from keratin that is useful for many aspects of medical treatment of bone. The keratin material is preferably S-sulfonated and enriched in intermediate filament proteins of high molecular weight. The keratin material may be porous for use as a bone replacement and augmentation product but also provided is the use of dense keratin materials in bone treatment for use as an internal fixation appliance in the treatment of bone fractures and bone regeneration, and a method for preparing the keratin material for use in the preservation, restoration and development of form and function of bone.
REFERENCES:
patent: 2591945 (1952-04-01), Koerner et al.
patent: 3567363 (1971-03-01), Wolfram
patent: 3619116 (1971-11-01), Saville
patent: 3644084 (1972-02-01), Hsiung et al.
patent: 3883647 (1975-05-01), Geller
patent: 4135942 (1979-01-01), Kikkawa
patent: 4172073 (1979-10-01), Kadri et al.
patent: 4407793 (1983-10-01), Akimora et al.
patent: 4775620 (1988-10-01), Cardiff et al.
patent: 4895722 (1990-01-01), Abe et al.
patent: 4904602 (1990-02-01), Pigiet et al.
patent: 4948876 (1990-08-01), Bore et al.
patent: 4969880 (1990-11-01), Zamierowski
patent: 5071441 (1991-12-01), Schnetzinger et al.
patent: 5154916 (1992-10-01), Arraudeau et al.
patent: 5358935 (1994-10-01), Smith et al.
patent: 5460967 (1995-10-01), Fink
patent: 5602094 (1997-02-01), Goddard
patent: 5763583 (1998-06-01), Arai et al.
patent: 5830481 (1998-11-01), Cauwet-Martin et al.
patent: 5932552 (1999-08-01), Blanchard et al.
patent: 5972385 (1999-10-01), Lie et al.
patent: 6039962 (2000-03-01), Cauwet-Martin et al.
patent: 6110487 (2000-08-01), Timmons et al.
patent: 6124265 (2000-09-01), Timmons et al.
patent: 6159495 (2000-12-01), Timmons et al.
patent: 6203574 (2001-03-01), Kawamura
patent: 6312674 (2001-11-01), Maubru et al.
patent: 6432435 (2002-08-01), Timmons et al.
patent: 6514744 (2003-02-01), Murata et al.
patent: 6544548 (2003-04-01), Siller-Jackson
patent: 6783546 (2004-08-01), Zucherman
patent: 6846940 (2005-01-01), Gaetani et al.
patent: 7169896 (2007-01-01), Schrooyen et al.
patent: 2001/0018614 (2001-08-01), Bianchi
patent: 2002/0004068 (2002-01-01), DiDrusco
patent: 2002/0013408 (2002-01-01), Rhee
patent: 2002/0035046 (2002-03-01), Lukenbach et al.
patent: 2002/0183858 (2002-12-01), Contiliano
patent: 2003/0035820 (2003-02-01), Timmons et al.
patent: 2003/0039676 (2003-02-01), Boyce et al.
patent: 2006/0165635 (2006-07-01), Kelly et al.
patent: 2006/0205652 (2006-09-01), Zamora et al.
patent: 1403643 (2003-03-01), None
patent: 1425813 (2003-06-01), None
patent: 0 628 573 (1994-12-01), None
patent: 1 201 736 (2005-04-01), None
patent: 1503640 (1967-12-01), None
patent: 2687577 (1993-08-01), None
patent: 2 115 427 (1983-09-01), None
patent: 53-119900 (1978-10-01), None
patent: 54 137064 (1979-10-01), None
patent: 63-229058 (1988-09-01), None
patent: 63-301809 (1988-12-01), None
patent: 03-007596 (1991-01-01), None
patent: 03-294297 (1991-12-01), None
patent: 05-222100 (1993-08-01), None
patent: 05-320358 (1993-12-01), None
patent: 06-100600 (1994-04-01), None
patent: 06-220713 (1994-08-01), None
patent: 06 192433 (1994-12-01), None
patent: WO 92/02238 (1992-02-01), None
patent: WO 98/51265 (1998-11-01), None
patent: WO 99/18922 (1999-04-01), None
patent: WO 99/19005 (1999-04-01), None
patent: WO 99/26570 (1999-06-01), None
patent: WO 00/23039 (2000-04-01), None
patent: WO 00/41739 (2000-07-01), None
patent: WO 00/70049 (2000-11-01), None
patent: WO 02/09659 (2002-02-01), None
patent: WO 03/011894 (2002-02-01), None
patent: WO 03/018673 (2003-03-01), None
Maclaren, John A., et al., “Wool Science The Chemical Reactivity of the Wool Fibre”, pp. 12-14, 1981.
Hunter, Emma A.L., et al., “Cysteine and Methionin Supplementation Modulate the Effect of Tumor Necrosis Factor a on Protein Synthesis, Glutathione and Zinc Concentration of Liver and Lung in Rats Fed a Low Protein Diet”, American Institute of Nutrition, vol. 124, No. 12, pp. 2319-2328, 1994.
Homandberg, G.A., et al., “Fibronectin Fragment Mediated Cartilage Chondrolysis. I. Suppression by Anti-Oxidants”, Biochemica et Biophysica Acta, vol. 1317, pp. 134-142, 1996.
Parcell, Stephen, “Sulphur in Human Nutrition and Applications in Medicine”, Alternative Medicine Review, vol. 7, No. 1, pp. 22-44, 2002.
Zafarullah, M., et al., “Molecular Mechanisms of N-Acetylcysteine Actions”, Cellular and Molecular Life Sciences, vol. 60, No. 1, pp. 6-20, 2003.
Hummel, Klaus M., et al., “Cysteine Proteinase Cathepsin K mRNA Is Expressed in Synovium of Patients with Rheumatoid Arthritis and Is Detected at Sites of Synovial Bone Destruction”, Journal of Rheumatology, vol. 25, No. 10, pp. 1887-1984, 1998.
Bradley, Helen, et al., “Sulfate Metabolism is Abnormal in Patients with Rheumatoid Arthiritis”, Journal of Rheumatology, vol. 21, No. 7, pp. 1192-1196, 1994.
Wilkinson, L.J., et al., “Cysteine Diosygenase: Modulation of Expression in Human Cell Lines by Cytokines and Control of Sulphate Production”, Toxicology in Vitro, vol. 16, pp. 481-483, 2002.
Tappaz, M.L., “Taurine Biosynthetic Enzymes and Taurine Transporter: Molecular Identification and Regulations”, Neurochemical Research, vol. 29, No. 1, pp. 83-96, Jan. 2004.
Kontny, E., et al., “Impaired Generation of Taurine Chloramine by Synovial Fluid Neutrophils of Rheumatoid Arthritis Patients”, Amino Acids, vol. 24, No. 4, pp. 415-418, 2002.
Roughley, Peter J., et al., “Cartilage Proteoglycans: Structure and Potential Functions”, Microscopy Research and Technique, vol. 28, No. 5, pp. 385-397, 1994.
Rossi, Antonio, et al., “In Vitro Proteoglycan Sulfation Derived from Sulfhydryl Compounds in Sulfate Transporter Chondrodysplasias”, Pediatric Pathology and Molecular Medicine, vol. 22, No. 4, pp. 311-321, 2003.
Kusche-Gullberg, Marion, et al., “Sulfotransferases in Glycosaminoglycan Biosynthesis”, Current Opinion in Structural Biology, vol. 13, pp. 605-611, 2003.
Rath, Virginia L., “Sulfotransferase Structural Biology and Inhibitor Discovery”, Drug Discovery Today vol. 9, No. 23, pp. 1003-1011, Dec. 2004.
Venkatachalam, K.V., “Human 3′-phosphoadenosine 5′-phosphosulfate (PAPS) Synthase: Biochemistry, Molecular Biology and Genetic Deficiency”, IUBMB Life, vol. 55, pp. 1-11, 2003.
Heyland, Daren K., et al., “Antioxidant Nutrients: A Systematic Review of Trace Elements and Vitamins in the Critically Ill Patient”, Intensive Care Med., vol. 31, pp. 327-337, 2005.
Elsayed, Nabil M., “Antioxidant Mobilization in Response to Oxidative Stress: A Dynamic Environmental-Nutritional Interaction”, Nutrition, vol. 17, pp. 828-834, 2001.
Serhan, Charles N., et al., “Resolution of Inflammation: The Beginning Programs the End”, Nature Immunology, vol. 6, No. 12, pp. 1191-1197, Dec. 2005.
Henson, Peter M., “Dampening Inflammation”, Nature Immunology, vol. 12, No. 12, pp. 1179-1182, Dec. 2005.
Verbruggen, G., “Chondroprotective Drugs in Degenerative Joint Diseases”, Journal of Rheumatology, vo.. 45, pp. 129-138, 2006.
Largo, R., et al., “Glucosomine Inhibits IL-1b-Induced NFkB Activation in Human Osteoarthritic Chondrocytes”, OsteoArthritis and Cartilage, vol. 11, pp. 290-298, 2003.
Chan, P.S., et al., “Glucosamine and Chondroitin Sulfate Regulate Gene Expression and Synthesis of Nitric Oxide and Prostaglandin E2 in Articular Cartilage Explants”, OsteArthritis and Cartilage, vol. 13, pp. 387-394, 2005.
Rassin, D.K., et al., “Nutritional Approaches to Improve Cognitive Development During Infancy: Antioxidant Compounds”, Acta Paediatr Suppl., vol. 442, pp. 34-41, 2003.
Brugge, Karen L., et al., “The Role of Alterations in Free Radical Metabolism in Mediating Cognitive Impairments in Down's Syndrome”, EXS, vol. 62, pp. 190-198, 1992.
del Marmol, Veronique,
Dias Subasinghe Nisanke George Premalal Jayantha
Kelly Robert James
Peplow Philip Victor
Roddick-Lanzilotta Alisa Dawn
Keraplast Technologies Ltd.
Monshipouri Maryam
Tsay Marsha M
Vinson & Elkins LLP
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