Orthomolecular method of treating sickle cell disease

Details Orthomolecular method of treating sickle cell disease Orthomolecular method of treating sickle cell disease

1992-01-13

1993-01-05

Page, Thurman K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

549408, 514258, 514458, 514815, 514951, 514953, 514960, 514962, 514966, 424401, 424422, 424423, 424435, 424451, 424464, 424466, 424489, 544244, C07D47306, C07D31104, A01N 4354, A61K 31355

Patent

active

051772086

ABSTRACT:
A method for preventing the sickling of sickle cells in a patient having sickle cell disease, the method which comprises administering to the patient a therapeutically effective amount of a compound having the formula: ##STR1## wherein X.sup.- is selected from the group consisting of iodide, chloride, bromide, hydroxyl, nitrite, phosphate and acetate.

REFERENCES:
patent: 4390526 (1983-06-01), Gorecki et al.
patent: 4866052 (1989-09-01), Hider et al.
patent: 4983626 (1991-01-01), Ismail
"A decrease in Irreversibly Sickled Erythrocytes in Sickle Cell Anemia Patients Given Vitamin E", Natta et al., American Journal of Clinical Nut., May 1980, 33(5) pp. 968-971.
Batlle et al. "Two Cases of Infantile Porphyria Cutanea Tarda: Successful Treatment with Oral S-Adenosyl-L-Methionine and Low-Dose Oral Chloroquine", British Journal of Dermatology (1987), vol. 116, pp. 407-413.
Tangney et al. "Selected Indices of Micronutrient Status in Adult Patients with Sickle Cell Anemia (SCA)", American Journal of Hematology (1989), vol. 32.

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