Radiant energy – Ionic separation or analysis – With sample supply means
Patent
1997-01-31
2000-10-03
Anderson, Bruce C.
Radiant energy
Ionic separation or analysis
With sample supply means
B01D 5946, H01J 4900
Patent
active
RE036892&
ABSTRACT:
[The invention teaches the uses of a plurality of electric fields and of orthogonal spray configurations of vaporized analyte which combine so as to operate to enhance the efficiency of analyte detection and mass analysis with a mass spectrometer by reducing vapor in the vacuum system and concomitant noise. Several embodiments of the invention are described for purposes of illustration.] The invention relates to a method and apparatus for improving signal relative to noise without loss of ion collection efficiency in electrospray mass spectrometry, including liquid chromatography/mass spectrometry.
REFERENCES:
patent: Re34757 (1994-10-01), Smith
patent: 3867631 (1975-02-01), Briggs et al.
patent: 4137750 (1979-02-01), French et al.
patent: 4209696 (1980-06-01), Fite
patent: 4300044 (1981-11-01), Iribarne et al.
patent: 4531056 (1985-07-01), Labowsky et al.
patent: 4542293 (1985-09-01), Fenn et al.
patent: 4546253 (1985-10-01), Tsuchiya et al.
patent: 4641541 (1987-02-01), Sharp
patent: 4667100 (1987-05-01), Lagna
patent: 4746068 (1988-05-01), Goodley et al.
patent: 4842701 (1989-06-01), Smith et al.
patent: 4851700 (1989-07-01), Goodley
patent: 4861988 (1989-08-01), Henion et al.
patent: 4885076 (1989-12-01), Smith et al.
patent: 4935624 (1990-06-01), Henion et al.
patent: 4960991 (1990-10-01), Goodley et al.
patent: 4977320 (1990-12-01), Chowdhury et al.
patent: 4977785 (1990-12-01), Willoughby et al.
patent: 4982097 (1991-01-01), Slivon et al.
patent: 4994165 (1991-02-01), Lee et al.
patent: 4999493 (1991-03-01), Allen et al.
patent: 5015845 (1991-05-01), Allen et al.
patent: 5030826 (1991-07-01), Hansen
patent: 5051583 (1991-09-01), Mimura et al.
patent: 5115131 (1992-05-01), Jorgenson et al.
patent: 5122670 (1992-06-01), Mylchreest et al.
patent: 5157260 (1992-10-01), Mylchreest et al.
patent: 5162650 (1992-11-01), Bier
patent: 5162651 (1992-11-01), Kato
patent: 5170053 (1992-12-01), Hail et al.
patent: 5171990 (1992-12-01), Mylchreest
patent: 5223226 (1993-06-01), Wittmer et al.
patent: 5235186 (1993-08-01), Robins
patent: 5245186 (1993-09-01), Chait et al.
patent: 5247842 (1993-09-01), Kaufman et al.
patent: 5285064 (1994-02-01), Wiloughby
patent: 5289003 (1994-02-01), Musser
patent: 5304798 (1994-04-01), Tomany et al.
patent: 5306412 (1994-04-01), Whitehouse et al.
patent: 5331160 (1994-07-01), Whitt
patent: 5349186 (1994-09-01), Ikonomou et al.
patent: 5376789 (1994-12-01), Stenhagen
patent: 5393975 (1995-02-01), Hail et al.
patent: 5406079 (1995-04-01), Kato
patent: 5412208 (1995-05-01), Covey et al.
patent: 5416322 (1995-05-01), Chace et al.
patent: 5423964 (1995-06-01), Smith et al.
patent: 5436446 (1995-07-01), Jarrell et al.
patent: 5481107 (1996-01-01), Takada et al.
patent: 5505832 (1996-04-01), Laukien et al.
patent: 5559326 (1996-09-01), Goodley et al.
Apffel et al., "Gas-Nebulized Direct Liquid Introduction Interface for Liquid Chromatography/Mass Spectrometry", Anal. Chem., 1983, vol. 55, p. 2280-2284 No Month.
Bruins et al., "Ion Spray Interface for Combined Liquid Chromatography/Atmospheric Pressure Ionization Mass Spectrometry", Anal. Chem., 1987, vol. 59, p. 2642-2646 No Month.
Whitehouse et al., "Electrospray Interface for Liquid Chromatographs and Mass Spectrometers", Anal. Chem., 1985, vol. 57, No. 3, p. 675-679 No Month.
Garcia et al., "Optimization of the Atmospheric Pressure Chemical Ionization Liquid Chromatography Mass Spectrometry Interface",J. Am. Soc. Mass. Spectrom.,1996, vol. 7, No. 1, p. 59-65. No Month.
Hagiwara et al., "Optimum Needle Materials of the Corona Discharge Electrode for Quantitative Analysis by Liquid Chromatography/Atmospheric Pressure Chemical Ionization-Mass Spectrometry", J. Mass. Spectrom. Soc. Jpn., 1995, vol. 43, No. 6, p. 365-371. No Month.
Takada et al., "Atmospheric Pressure Chemical Ionization Interface for Capillary Electrophoresis/Mass Spectrometry", Anal. Chem., Apr. 15, 1995, vol. 67, No. 8, p. 1474-1476.
Doerge et al., "Multiresidue Analysis of Sulfonamides Using Liquid Chromatography with Atmospheric Pressure Chemical Ionization Mass Spectrometry", Rapid Communications in Mass Spectrom., Dec. 1993, vol. 7, No. 12, p. 1126-1130.
Willoughby et al., "Monodisperse Aerosol Generation Interface for Combining Liquid Chromatography with Mass Spectroscopy", Anal. Chem., 1984, vol. 56, p. 2626-2631 No Month.
Yamashita et al., "Electrospray Ion Source. Another Variation on the Free-Jet Theme", J. Phys. Chem., 1984, vol. 88, p. 4451-4459.
Kambara et al., "Ionization Charateristics of Atmospheric Pressure Ionization by Corona Discharge", Mass Spectroscopy, Sep. 1976, vol. 24, No. 3, p. 229-236.
Lee et al., "Real-Time Reaction Monitoring by Continuous-Introduction Ion-Spray Tandem Mass Spectrometry", J. Am. Chem. Soc., 1989, vol. III, No. 13, p. 4600-4604.
Apffel, Jr. James A.
Bertsch James L.
Goodley Paul C.
Henry Kent D.
Werlich Mark H.
Agilent Technologies
Anderson Bruce C.
LandOfFree
Orthogonal ion sampling for electrospray .[.LC/MS.]. mass spectr does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Orthogonal ion sampling for electrospray .[.LC/MS.]. mass spectr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Orthogonal ion sampling for electrospray .[.LC/MS.]. mass spectr will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-183618