Orthogonal ion sampling for APCI mass spectrometry

Details Orthogonal ion sampling for APCI mass spectrometry Orthogonal ion sampling for APCI mass spectrometry

1997-02-03

1998-05-12

Nguyen, Kiet T.

Radiant energy

Ionic separation or analysis

With sample supply means

H01J 4926

Patent

active

057509883

ABSTRACT:
A method apparatus wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The method and apparatus provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.

REFERENCES:
patent: Re34757 (1994-10-01), Smith et al.
patent: 3867631 (1975-02-01), Briggs et al.
patent: 4137750 (1979-02-01), French et al.
patent: 4209696 (1980-06-01), Fite
patent: 4300044 (1981-11-01), Iribarne et al.
patent: 4531056 (1985-07-01), Labowsky et al.
patent: 4542293 (1985-09-01), Fenn et al.
patent: 4546253 (1985-10-01), Tsuchiya et al.
patent: 4641541 (1987-02-01), Sharp
patent: 4667100 (1987-05-01), Lagna
patent: 4746068 (1988-05-01), Goodley et al.
patent: 4842701 (1989-06-01), Smith et al.
patent: 4851700 (1989-07-01), Goodley
patent: 4861988 (1989-08-01), Henion et al.
patent: 4885076 (1989-12-01), Smith et al.
patent: 4935624 (1990-06-01), Henion et al.
patent: 4960991 (1990-10-01), Goodley et al.
patent: 4977320 (1990-12-01), Chowdhury et al.
patent: 4977785 (1990-12-01), Wileoughby et al.
patent: 4982097 (1991-01-01), Slivon et al.
patent: 4994165 (1991-02-01), Lee et al.
patent: 4999493 (1991-03-01), Allen et al.
patent: 5015845 (1991-05-01), Allen et al.
patent: 5030826 (1991-07-01), Hansen
patent: 5051583 (1991-09-01), Mimura et al.
patent: 5115131 (1992-05-01), Jorgenson et al.
patent: 5122670 (1992-06-01), Mylchreest et al.
patent: 5157260 (1992-10-01), Mylchreest et al.
patent: 5162650 (1992-11-01), Bier
patent: 5162651 (1992-11-01), Kato
patent: 5170053 (1992-12-01), Hail et al.
patent: 5171990 (1992-12-01), Mylchreest et al.
patent: 5223226 (1993-06-01), Wittmer et al.
patent: 5235186 (1993-08-01), Robins
patent: 5245186 (1993-09-01), Chait et al.
patent: 5247842 (1993-09-01), Kaufman et al.
patent: 5285064 (1994-02-01), Willoughby
patent: 5289003 (1994-02-01), Musser
patent: 5304798 (1994-04-01), Tomany et al.
patent: 5306412 (1994-04-01), Whitehouse et al.
patent: 5331160 (1994-07-01), Whitt
patent: 5349186 (1994-09-01), Ikonomou et al.
patent: 5376789 (1994-12-01), Stenhagen
patent: 5393975 (1995-02-01), Hail et al.
patent: 5406079 (1995-04-01), Kato
patent: 5412208 (1995-05-01), Covey et al.
patent: 5416322 (1995-05-01), Chace et al.
patent: 5423964 (1995-06-01), Smith et al.
patent: 5436446 (1995-07-01), Jarrell et al.
patent: 5481107 (1996-01-01), Takada et al.
patent: 5485016 (1996-01-01), Irie et al.
patent: 5495108 (1996-02-01), Apffel, Jr. et al.
patent: 5505832 (1996-04-01), Laukien et al.
patent: 5559326 (1996-09-01), Goodley et al.
Lee et al., "Real-Time Reaction Monitoring by Continuous-Introduction Ion-Spray Tandem Mass Spectrometry", J. Am. Chem. Soc., 1989, vol. III, No. 13, pp. 4600-4604.
Apffel et al., "Gas-Nebulized Direct Liquid Introduction Interface for Liquid Chromatography/Mass Spectrometry", Anal Chem., 1983, vol. 55, pp. 2280-2284.
Bruins et al., "Ion Spray Interface for Combined Liquid Chromatography/Atmospheric Pressure Ionization Mass Spectrometry", Anal.Chem., 1987, vol. 59, pp. 2642-2646.
Whitehouse et al., "Electrospray Interface for Liquid Chromatographs and Mass Spectrometers", Anal. Chem., 1985, vol. 57, No.3, pp. 675-679.
Garcia et al., "Optimization of the Atmospheric Pressure Chemical Ionization Liquid Chromatography Mass Spectrometry Interface", J.Am. Soc.Mass.Spectrom.,1996, vol. 7, No. 1, pp. 59-65.
Hagiwara et al., "Optimum Needle Materials of the Corona Discharge Electrode for Quantitative Analysis by Liquid Chromatography/Atmospheric Pressure Chemical Ionization-Mass Spectrometry", J.Mass Spectrom.Soc.Jpn., 1995, vol. 43, No. 6, pp. 365-371.
Takada et al., "Atmospheric Pressure Chemical Ionization Interface for Capillary Electrophoresis/Mass Spectrometry", Anal.Chem., Apr. 15, 1995, vol. 67, No. 8, pp. 1474-1476.
Doerge et al., "Multiresidue Analysis of Sulfonamides Using Liquid Chromatography with Atmospheric Pressure Chemical Ionization Mass Spectrometry", Rapid Communications in Mass Spectrom., Dec. 1993, vol. 7, No. 12, pp. 1126-1130.
Willoughby et al., "Monodisperse Aerosol Generation Interface for Combining Liquid Chromatography with Mass Spectroscopy", Anal.Chem., 1984, vol. 56, pp. 2626-2631.
Yamashita et al., "Electrospray Ion Source. Another Variation on the Free-Jet Theme", J.Phys.Chem., 1984, vol. 88, pp. 4451-4459.
Kambara et al., "Ionization Characteristics of Atmospheric Pressure Ionization by Corona Discharge", Mass Spectroscopy, Sep. 1976, vol. 24, No. 3, pp. 229-236.

Affiliated with

Also associated with

Rating

Orthogonal ion sampling for APCI mass spectrometry does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Orthogonal ion sampling for APCI mass spectrometry, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Orthogonal ion sampling for APCI mass spectrometry will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-982772