Orthoester reagents for use as protecting groups in oligonucleot

Details Orthoester reagents for use as protecting groups in oligonucleot Orthoester reagents for use as protecting groups in oligonucleot

1997-12-19

1999-12-28

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

558435, 568595, 568597, 568598, 568614, C07C25511, C07C25549, C07C 4330, C07C 4332

Patent

active

060084006

ABSTRACT:
Phosphoramidite oligonucleotide synthesis is facilitated by the use of fluoride-labile 5' silyl protecting groups. RNA synthesis is improved by the use of 2 orthoester protecting groups. Reactions are conducted on a solid phase support and acidic deprotection conditions are avoided, as is the necessity of oxidizing the phosphite linkage between each coupling reaction.

REFERENCES:
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4999428 (1991-03-01), Saksena et al.
patent: 5015739 (1991-05-01), Saksena et al.

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