Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-08-28
1998-12-15
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514522, 514599, 514616, 514821, 514824, 514866, 514921, 558412, 558413, 567 74, 567154, 567162, A61K 31165
Patent
active
058497960
ABSTRACT:
Ortho-substituted benzoic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have the given meanings, and Q is guanidyl, and also their physiologically harmless salts, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter. In addition, the compounds of the formula I, in which R.sup.1 to R.sup.3 and also Q have the given meanings, are suitable for use as valuable intermediates for the preparation of medicaments, in particular of inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
REFERENCES:
patent: 5373024 (1994-12-01), Lang et al.
Database Registry, Chemical Abstracts Service, Columbus OH, US.
Abstract of EP 690,048.
Baumgarth Manfred
Beier Norbert
Dorsch Dieter
Gericke Rolf
Minck Klaus-Otto
Merck Patent Gelsellschaft mit Beschrankter Haftung
O'Sullivan Peter
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