Ornithine derivative

Details Ornithine derivative Ornithine derivative

2008-03-25

2011-10-04

Andres, Janet (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S393000, C546S121000, C546S156000, C546S169000, C546S175000, C548S374100, C548S491000, C548S537000, C514S249000, C514S255030, C514S300000, C514S311000, C514S312000, C514S423000

Reexamination Certificate

active

08030489

ABSTRACT:
Provided is a compound which is useful as a therapeutic agent for chronic renal insufficiency and a therapeutic agent for diabetic nephropathy.The present inventors have made extensive studies on an ornithine derivative having an antagonistic action against an EP4 receptor, and as a result, they have found that by introducing cycloalkanediyl at a C terminal of the ornithine part of the compound of the present invention, the physicochemical properties such as solubility, and the like can be improved, thereby giving further preferred properties as a pharmaceutical. Therefore, they have completed the present invention.The compound of the present invention exhibits a good antagonistic action against an EP4 receptor, and thus, it is useful as a therapeutic agent for chronic renal insufficiency and diabetic nephropathy.

REFERENCES:
patent: 2005 061475 (2005-07-01), None
Dr. Florencio Zaragoza DörwaId, Side Reactions in Organic Synthesis, WILEY, p. IX, 1-15 (Jul. 25, 2005).
Martin et. al., Do Structurally Similar Molecules Have Similar Biological Activity?, 45(19) J. Med. Chem. 4350-4358 (2002).
Regan, EP2 and EP4 Prostanoid Receptor Signaling, 74 Life Sciences 143-153 (2003).

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