Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1996-12-31
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 692, 4352402, 4352551, 935 59, 935 70, 935 77, 53038821, C12Q 168, C12N 1500, C12N 115, C07K 1439
Patent
active
055893414
ABSTRACT:
Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said ORC protein selectively binds said binding target; and detecting the presence or absence of specific binding of said ORC protein to said binding target.
Bell Stephen P.
Foss Margit
Gavin Kimberly
Herskowitz Ira
Hidaka Masumi
Cold Spring Harbor Laboratory
Fleisher Mindy
Osman Richard Aron
The Regents of the University of California
Weiss Bonnie D.
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