Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-07
1997-03-25
Zitomer, Stephanie W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 6, 435 912, 536 243, 536 2433, C07H 2102, C07M 2104, C12Q 168, C12P 1934
Patent
active
056146183
ABSTRACT:
Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said ORC protein selectively binds said binding target; and detecting the presence or absence of specific binding of said ORC protein to said binding target.
REFERENCES:
Micklem et al. Nature 366:87-89 1993.
Bell Stephen P.
Foss Margit
Gavin Kimberly
Herskowitz Ira
Hidaka Masumi
Cold Spring Harbor Laboratory
Osman Richard Aron
Rees Dianne
The Regents of the University of California
Zitomer Stephanie W.
LandOfFree
Origin of replication complex genes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Origin of replication complex genes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Origin of replication complex genes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2204479