Orienting polymer domains for controlled drug delivery

Details Orienting polymer domains for controlled drug delivery Orienting polymer domains for controlled drug delivery

2011-06-21

2011-06-21

Foley, Shanon A (Department: 1619)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S422000, C427S002260, C604S500000

Reexamination Certificate

active

07964209

ABSTRACT:
The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphase separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices formed from the above techniques.

REFERENCES:
patent: 6545097 (2003-04-01), Pinchuk et al.
patent: 2003/0235603 (2003-12-01), Schwarz et al.
patent: 2004/0051201 (2004-03-01), Greenhalgh et al.
patent: 2004/0058887 (2004-03-01), Bowlin et al.
patent: 2004/0067301 (2004-04-01), Ding
patent: 2006/0184112 (2006-08-01), Horn et al.
patent: 2008/0018015 (2008-01-01), McHugh et al.
patent: 2005314526 (2005-11-01), None
patent: WO 02/076523 (2002-10-01), None
patent: WO 2006/047490 (2006-05-01), None
http://en.wikipedia.org/wiki/Electrospinning (Wikipedia).
Jeffrey Pyun et al., “Synthesis of Nanocomposite Organic/Inorganic Hybrid Materials Using Controlled/“Living” Radical Polymerization,”Chem. Mater., vol. 13, 2001, pp. 3436-3448.
Yoav Tsori et al., “Structural Changes in Block Copolymers: Coupling of Electric Field and Mobile Ions,”Physical Review Letters, vol. 90, No. 14, Apr. 11, 2003, pp. 145504-1-145504-4.
Yoav Tsori et al., “Thin Film Diblock Copolymers in Electric Field: Transition from Perpendicular to Parallel Lamellae,”Macromolecules, vol. 35, 2002, pp. 5161-5170.
T. Thurn-Albrecht et al., “Overcoming Interfacial Interactions with Electric Fields,”Macromolecules, vol. 33, 2000, pp. 3250-3253.
Figure: ma991896zf00001. Http://pubs.acs.org/isubscribe/journals/mamobx/33/i09/figures/ma991896zf00001.html. Jul. 18, 2003 download.
Tsori, Y. et al., “Diblock copolymer ordering induced by patterned surfaces,” Europhsyics Letters, 53 (6), Mar. 15, 2001, pp. 722-728.
Tsori, Y, et al., “Ordering Mechanisms in Confined Diblock Copolymers,” Interface Science 11, 2003, pp. 259-268.
Tsori, Y. et al., “Ordered Morphologies of Confined Diblock Copolymers,” Mat. Res. Soc. Symp. Proc. vol. 651, pp. T8.1.1-T8.1.11, 2001.
Tsori, Y. et al., Diblock copolymer thin films: Parallel and perpendicular lamellar phases in the week segregation limit, The European Physical Journal E 5, pp. 605-614, 2001.
Tsori, Y., et al., “Thin Film Diblock Copolymers in Electric Field: Transition from Perpendicular to Parallel Lamellae,” Macromolecules 2002, 35, published May 18, 2002, pp. 5161-5170.
Tsori, Y. et al., Structural Changes in Block Copolymers: Coupling of Electric Field and Mobile Ions, Physical Review Letters, vol. 90, No. 14, Apr. 11, 2003, pp. 145504-1-145504-4.
Böltau, Martin et al., “Surface-induced structure formation of polymer blends on patterned substrates,” Nature, vol. 391, Feb. 1998, pp. 877-879.
Elhadj, S., et al., “Orientation of self-assembled block copolymer cylinders perpendicular to electric field in mesoscale film,” Applied Physics Letters, vol. 82, No. 6, Feb. 10, 2003, pp. 871-873.

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