Optical: systems and elements – Compound lens system – Microscope
Reexamination Certificate
2007-06-19
2007-06-19
Amari, Alessandro (Department: 2872)
Optical: systems and elements
Compound lens system
Microscope
Reexamination Certificate
active
11002834
ABSTRACT:
A method for performing differential interference contrast microscopy on a specimen includes collecting at least two images with illumination respectively having first and second beam-shear directions relative to a rotational orientation of the specimen, determining data associated with an intensity distribution of each of the collected images, and calculating values having a spatial distribution that is substantially independent of the rotational orientation of the specimen. A differential interference contrast microscope includes a beam-shearing assembly that includes a beam-shearing component. The beam-shearing assembly is configured to provide a variable shear vector without a movement of the beam-shearing component. A microscopy system can include the microscope and an imaging-control unit.
REFERENCES:
patent: 2601175 (1952-06-01), Smith
patent: 2924142 (1960-02-01), Nomarski
patent: 4795246 (1989-01-01), Lord
patent: 5317644 (1994-05-01), Kenyon et al.
patent: 6128127 (2000-10-01), Kusaka
patent: 6433876 (2002-08-01), Kuhn
patent: 2003/0161038 (2003-08-01), Tobben et al.
patent: 2004/0017609 (2004-01-01), Danz et al.
http://microscope.fsu.edu/primer/techniques/dic/dicintro.html; Nov. 15, 2004 1-19.
Noguchi et al., “Measurement of 2-D Birefringence Distribution,” SPIE vol. 1720 (1992) 367-378.
Holzwarth et al., “Improving DIC Microscopy with Polarization Modulation,” Journal of Microscopy, vol. 188, pt. 3, Dec. 1997, pp. 249-254.
Holzwarth et al., “Differential Interference Contrast Microscopy Gets,” Biophotonics International Jul./Aug. 2001, pp. 46-47.
Holzwarth et al., “Polarization-Modulated Differential-Interference Contrast Microscopy with a Variable Retarder,” Applied Optics, vol. 39, No. 34, Dec. 1, 2000, pp. 6288-6294.
Preza et al., “Imaging Models for Three-Dimensional Transmitted-Light DIC Microscopy,” Scientce & Technology, 1996, pp. 1-13.
Shribak et al., “Techniques for Fast and Sensitive Measurements of Two-Dimensional Birefringence Distributions,” Applied Optics, vol. 42, No. 16, Jun. 1, 2003, pp. 3009-3017.
Amison et al., “Linear Phase Imaging Using Differential Interference Contrast Microscopy,” Journal of Microscopy, vol. 214, Pt. 1, Apr. 2004, pp. 7-12.
Preza, “Rotational-Diversity Phase Estimation From Differential-Interference-Contrast Micrscopy Images,” Journal of Optical Soc. Am. A. , vol. 17, No. 3, pp. 415-424.
Inque, Cell Division and the Mitotic Spindle, The Journal of Cell Biology, vol. 91, No. 3, Pt. 2, Dec. 1981, 131s-147s.
Bajor et al., “Automated Polarimeter-Macroscope for Optical Mapping of Birefringence, Azimuths, and Transmission in Large Area Wafers. Part II. Measurement Setup and Results,” Rev. Sci. Instrum. 66 (4) Apr. 1995, pp. 2991-2995.
Inque, “Video Image Processing Greatly Enchances Contrast, Quality, and Speed in Polarization-Based Microscopy,” The Journal of Cell Biology, vol. 89, May 1981, pp. 346-356.
Oldenbourg et al., “New Polarized Light Microscope with Precision Universal Compensator,” Journal of Microscopy, vol. 180, Pt. 2, Nov. 1995, pp. 140-147.
Hogan, “Getting the Small Picture,” Photonics Spectra, Apr. 2003, pp. 58-64.
Otani et al., “Two-Dimensional Birefringence Measurement Using the Phase Shifting Technique,” SPIE vol. 1720 (1992), pp. 346-354.
Glazer et al., “An Automatic Optical Imaging System for Birefringent Media,” Proc. R. Soc. Land A. (1996), pp. 2751-2765.
Allen et al., “Video-Enhanced Contrast Polarization (AVEC-POL) Microscopy: A New Method Applied to the Detection of Birefringence in the Motile Reticulopodial Network of Allogromia Laticollaris,” Cell Motility, (1981) 1:275-289.
Noguchi et al., “Measurement of 2-3 Birefringence Distribution,” SPIE vol. 1720 (1992) 367-378.
Mei et al., “Fast Imaging Polarimetry with Precision Universal Compensator,” SPIE vol. 2265, pp. 29-39.
Inque, “Cell Division and the Mitotic Spindle,” The Journal of Cell Biology, vol. 91, No. 3, Pr. 2, Dec. 1981, pp. 131s-147s.
Bajor et al., “Automated Polarimeter-Macroscope for Optical Mapping of Birefringence, Azimuths, and Transmission in Large Area Wafers.,” Rev. Sci. Instrum. 66 (4), Apr. 1995, pp. 2991-2995.
Holzwarth et al, “Polarization-Modulated Differential-Interference Contrast Microscopy with a Variable Retarder,” Applied Optics, vol. 39, No. 34, Dec. 1, 2000, pp. 6288-6294.
Holzwarth et al., “Improving DIC Microscopy with Polarization Modulation,” Journal of Microscopy, vol. 188, Pt., 3, Dec. 1997, pp. 249-254.
Allen et al., “The Zeiss-Nomarski Differential Interference Equipment for Transmitted-Light Microscopy,” 69, (4), pp. 193-221.
Holzwarth et al., “Differential Interference Contrast Microscopy Gets Supercharged,” Biophotonics International, 8 (6), pp. 46-47.
Amari Alessandro
Marine Biological Laboratory
Wolf Greenfield & Sacks P.C.
LandOfFree
Orientation independent differential interference contrast... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Orientation independent differential interference contrast..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Orientation independent differential interference contrast... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3829593